{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:02:34Z","timestamp":1773118954084,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify predictors of left ventricular ejection fraction (LVEF) improvement in patients with newly detected cardiomyopathy using wearable cardioverter defibrillators (WCDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>WCDs are useful in preventing sudden cardiac death in patients with reduced LVEF &lt;35% while awaiting implantable cardioverter defibrillator (ICD) placement. In many patients, LVEF improves and an ICD is not indicated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who received WCDs from November 2013 to November 2015 were identified and followed over a period of 2\u2009years. Clinical variables were examined. The primary outcome was improvement in LVEF \u226535%. Predictors of outcome were determined using a multivariate logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 179 patients were followed. Median age was 65 (interquartile range [IQR]: 56, 73) years, 69.3% were men. Median baseline LVEF was 20% (IQR: 15, 30). LVEF improved \u226535% in 47.5% patients, with patients being younger (62 vs 68.5\u2009years, <jats:italic>P<\/jats:italic> = .006), having lower blood urea nitrogen (BUN) (19 vs 24\u2009mg\/dL, <jats:italic>P<\/jats:italic> = .002), fewer left bundle branch block (LBBB 9.5% vs 25.8%, <jats:italic>P<\/jats:italic> = .004), shorter QRS duration (98 vs 112\u2009ms, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and higher use of angiotensin converting enzyme inhibitors (ACEI)\/angiotensin receptor blockers (ARB) (92.9% vs 74.4%, <jats:italic>P<\/jats:italic> = .001) compared to those without LVEF improvement. Absence of LBBB (odds ratio [OR] 0.28, 95% confidence interval [CI] 0.11\u20100.70), lower BUN (OR 0.13, 95% CI 0.02\u20100.76), and ACEI\/ARB use (OR 3.53, 95% CI 1.28\u20109.69) were identified as independent predictors. Ventricular tachycardia\/ventricular fibrillation was observed in three patients, all of whom received successful WCD shocks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Absence of LBBB, lower BUN, and ACEI\/ARB use predicts LVEF improvement. WCDs help treat arrhythmic events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23295","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T19:56:53Z","timestamp":1576871813000},"page":"260-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Absence of left bundle branch block and blood urea nitrogen predict improvement in left ventricular ejection fraction in patients with cardiomyopathy and wearable cardioverter defibrillators"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5971-2158","authenticated-orcid":false,"given":"Nikhil A.","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Cardiology Lehigh Valley Health Network  Allentown Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nashwa","family":"Abdulsalam","sequence":"additional","affiliation":[{"name":"Department of Cardiology University 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