{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:17:27Z","timestamp":1778123847488,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The optimal antiplatelet therapy after percutaneous coronary intervention (PCI) remains to be elucidated. Monotherapy with a P2Y12 inhibitor may be inferior to dual antiplatelet therapy in patients after PCI. PubMed, EMBASE (by Ovidsp), Web of Science, and The Cochrane Library were searched from database inception to 2 October 2019. The composite of cardiovascular outcomes, all\u2010cause mortality, myocardial infarction (MI), stroke, stent thrombosis, and major bleeding were evaluated. Pooled outcomes were presented as relative risk (RR) and 95% confidence intervals (CIs). A total of four trials randomizing 29\u2009089 participants were included. Compared with the dual antiplatelet therapy group (n = 14\u2009559), the P2Y12 inhibitor monotherapy group (n = 14\u2009530) significantly decreased the incidence of bleeding events (2.0% vs 3.1%; RR: 0.60; 95% CI: 0.43\u20100.84; <jats:italic>P<\/jats:italic> =\u2009.005). There were no significant differences in all\u2010cause mortality (1.3% vs 1.5%; RR: 0.87; 95% CI, 0.71\u20101.06; <jats:italic>P<\/jats:italic> =\u2009.16), myocardial infarction (2.1% vs 1.9%; RR, 1.06; 95% CI, 0.90\u20101.25; <jats:italic>P<\/jats:italic> =\u2009.46), stroke (0.6% vs 0.5%; RR, 1.18; 95% CI, 0.67\u20102.07; <jats:italic>P<\/jats:italic> =\u2009.57), or stent thrombosis (0.5% vs 0.4%; RR, 1.14; 95% CI, 0.81\u20101.61; <jats:italic>P<\/jats:italic> =\u2009.44) between the two groups. P2Y12 inhibitor monotherapy did not show any significant difference in the adverse cardiac and cerebrovascular events, but markedly decreased the risk of bleeding among patients after PCI vs dual antiplatelet therapy. However, it still needs to be further confirmed due to limited data.<\/jats:p>","DOI":"10.1002\/clc.23305","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T12:49:00Z","timestamp":1574945340000},"page":"235-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The efficacy and safety of P2Y12 inhibitor monotherapy in patients after percutaneous coronary intervention"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2368-6896","authenticated-orcid":false,"given":"Liman","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglu","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuiqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xizhen","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.513"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09457-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002816"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_8_11_1","unstructured":"HigginsJ AltmanD SterneJ. 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