{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:28:28Z","timestamp":1781335708943,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","award":["GPP3"],"award-info":[{"award-number":["GPP3"]}],"id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of antiarrhythmic drugs for atrial fibrillation\/atrial flutter (AF\/AFL) after catheter ablation is not well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that changing the myocardial substrate by ablation may alter the responsiveness to dronedarone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the efficacy and safety of dronedarone in the treatment of paroxysmal\/persistent atrial fibrillation\/atrial flutter (AF\/AFL) post\u2010ablation, based on a post hoc analysis of the ATHENA study. A total of 196 patients (dronedarone 90, placebo 106) had an ablation for AF\/AFL before study entry. In these patients, the effect of treatment on the first hospitalization because of cardiovascular (CV) events\/all\u2010cause death was assessed, as was AF\/AFL recurrence in individuals with sinus rhythm at baseline. The safety of dronedarone vs placebo was also determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with prior ablation, dronedarone reduced the risk of AF\/AFL recurrence (hazard ratio [HR]: 0.65 [95% confidence interval [CI]: 0.42, 1.00]; <jats:italic>P<\/jats:italic> &lt;\u2009.05) as well as the median time to first AF\/AFL recurrence (561 vs 180\u2009days) compared with placebo. The HR for first CV hospitalization\/all\u2010cause death with dronedarone vs placebo was 0.98 (95% CI: 0.62, 1.53; <jats:italic>P<\/jats:italic> =\u2009.91). Rates of treatment\u2010emergent adverse events were 83.1% vs 75.5% and rates of serious TEAEs were 27.0% vs 18.9% in the dronedarone and placebo groups, respectively. One death occurred with dronedarone (not treatment\u2010emergent) and five occurred with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with prior ablation for AF\/AFL, dronedarone reduced the risk of AF\/AFL recurrence compared with placebo, but not the risk of first CV hospitalization\/all\u2010cause death. Safety outcomes were consistent with those of the overall ATHENA study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23309","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T12:40:25Z","timestamp":1577191225000},"page":"291-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and safety of dronedarone in patients with a prior ablation for atrial fibrillation\/flutter: Insights from the ATHENA study"],"prefix":"10.1002","volume":"43","author":[{"given":"Mate","family":"Vamos","sequence":"first","affiliation":[{"name":"J.W. Goethe University, Department of Cardiology, Division of Clinical Electrophysiology  Frankfurt Germany"},{"name":"University of Szeged, Second Department of Medicine and Cardiology Center  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Calkins","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Department of Medicine, Cardiology  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Kowey","sequence":"additional","affiliation":[{"name":"Lankenau Heart Institute, Department of Cardiology  Wynnewood Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian T.","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Nordsjaellands Hospital Department of Cardiology and Epidemiology  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Corp dit Genti","sequence":"additional","affiliation":[{"name":"Sanofi\u2010Aventis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Wieloch","sequence":"additional","affiliation":[{"name":"Sanofi\u2010Aventis  Paris France"},{"name":"Lund University Department of Clinical Sciences  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Koren","sequence":"additional","affiliation":[{"name":"Sanofi US Inc.  Bridgewater New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H.","family":"Hohnloser","sequence":"additional","affiliation":[{"name":"J.W. Goethe University, Department of Cardiology, Division of Clinical Electrophysiology  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.05.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01950.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux274"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707855"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0693"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus153"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156121"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.04.016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.09.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803778"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01016.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.028"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht566"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut004"},{"issue":"17","key":"e_1_2_9_18_1","first-page":"1303","article-title":"Contemporary management of patients undergoing atrial fibrillation ablation: in\u2010hospital and 1\u2010year follow\u2010up findings from the ESC\u2010EHRA atrial fibrillation ablation long\u2010term registry","volume":"38","author":"Arbelo E","year":"2017","journal-title":"Eur Heart J"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"S112","article-title":"Antiarrhythmic drug therapy after radiofrequency catheter ablation in patients with atrial fibrillation","volume":"30","author":"Turco P","year":"2007","journal-title":"Pacing Clin Electrophysiol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2013.811982"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.23309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23309","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:02:11Z","timestamp":1694012531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,24]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/clc.23309"],"URL":"https:\/\/doi.org\/10.1002\/clc.23309","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,24]]},"assertion":[{"value":"2019-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}