{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:57:07Z","timestamp":1783191427254,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The second\u2010generation cryoballoon (CB2) is widely used for pulmonary vein (PV) isolation (PVI) in patients with paroxysmal atrial fibrillation (AF). Recently, the novel fourth\u2010generation CB (CB\u2010Advance PRO) was introduced, incorporating a shortened catheter tip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The aim of this study was to evaluate the feasibility and acute efficacy of PVI using the CB\u2010Advance PRO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 200 consecutive patients were analyzed. Hundred patients who underwent PVI due to symptomatic, drug\u2010refractory AF were treated with the CB\u2010Advance PRO (group I) and were included into this multicenter analysis. A group of 100 patients were treated with the CB2 and acted as controls (group II).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 739 of 739 PVs (100%) were successfully isolated. There was a nonsignificant trend in the incidence of online registration of PV signals between both groups (group I: 77.9% vs group II: 71.4%, <jats:italic>P<\/jats:italic> =\u2009.09). Median time to PVI (time to isolation [TTI]) and mean total freezing time were significantly shorter when using the CB\u2010Advance PRO (group I: 33 [23, 50] vs group II: 40 [26, 60] seconds and group I: 166\u2009\u00b1\u200929 vs group II: 183\u2009\u00b1\u200938\u2009seconds, <jats:italic>P<\/jats:italic> &lt;\u2009.01). In three of 100 (3%) patients of group I and one of 100 (1%) patients of group II, a transient phrenic nerve palsy occurred (<jats:italic>P<\/jats:italic> =\u2009.62).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of the novel CB\u2010Advance PRO is feasible and associated with a significant reduction in mean TTI and mean total freezing time as compared to the CB2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23328","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T19:01:11Z","timestamp":1582657271000},"page":"394-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Feasibility, safety, and acute efficacy of the fourth\u2010generation cryoballoon for ablation of atrial fibrillation: Another step forward?"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-8564","authenticated-orcid":false,"given":"Laura","family":"Rottner","sequence":"first","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibu","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Reissmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Warneke","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik Harburg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lemes","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wohlmuth","sequence":"additional","affiliation":[{"name":"Asklepios Proresearch Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifan","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u2010Heinz","family":"Kuck","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Metzner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik Harburg  Hamburg Germany"},{"name":"Department of Cardiology Universit\u00e4res Herzzentrum Hamburg Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rillig","sequence":"additional","affiliation":[{"name":"Department of Cardiology Asklepios Klinik St. Georg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw295"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003337"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946806"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-017-1199-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.02.030"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.01.024"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux219"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw233"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0944-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12856"},{"issue":"7","key":"e_1_2_8_13_1","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.005114","article-title":"Stand\u2010alone pulmonary vein isolation versus pulmonary vein isolation with additional substrate modification as index ablation procedures in patients with persistent and long\u2010standing persistent atrial fibrillation: the randomized Alster\u2010Lost\u2010AF Trial (Ablation at St. Georg Hospital for Long\u2010Standing Persistent Atrial Fibrillation)","volume":"10","author":"Fink T","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.088"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv092"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.07.007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.05.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.05.022"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux128"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000899"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-016-0987-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0890-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.06.020"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2018.0056"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.23328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23328","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:11:38Z","timestamp":1693969898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,25]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/clc.23328"],"URL":"https:\/\/doi.org\/10.1002\/clc.23328","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,25]]},"assertion":[{"value":"2019-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}