{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:58:24Z","timestamp":1761238704718,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interventional closure of the left atrial appendage (LAA) is an alternative option to stroke prophylaxis, particularly in multimorbid patients with a high risk of bleeding under oral anticoagulation. Due to the multiple comorbidities, the prognosis of patients is reduced, and the clinical benefit of the procedure is therefore questionable in the individual patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The present study aims to identify independent preprocedural risk factors to improve risk stratification in these highly selected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study consecutively included 128 patients who received an interventional LAA occlusion with Amplatzer device (St Jude Medical, St Paul, Minnesota). The preinterventional risk assessment was performed with the logistic European System for Cardiac Operative Risk Evaluation (EuroSCORE) II. The primary endpoint was all\u2010cause mortality. Secondary endpoints were thromboembolic events and severe bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a follow\u2010up of 781\u2009\u00b1\u2009498\u2009days the primary endpoint (all\u2010cause mortality) was reached in 35 patients (27%). The only independent predictor of mid\u2010term mortality was a logistic EuroSCORE II\u2009&gt;\u20092% (Hazard risk [HR] 4.55, confidence interval [CI] 1.599\u201012.966, <jats:italic>P<\/jats:italic> =\u2009.005). In our study, 33 patients (26%) suffered from end\u2010stage renal disease which was not associated with increased mortality (<jats:italic>P<\/jats:italic> =\u2009.371), increased thromboembolic events (<jats:italic>P<\/jats:italic> =\u2009.475), or severe bleeding (<jats:italic>P<\/jats:italic> =\u2009.613).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients undergoing interventional LAA occlusion, preprocedural assessment of logistic EuroSCORE II provide independent prognostic information. This parameter might help to improve risk stratification in these highly selected patients. In contrast, terminal renal failure was not associated with a significantly worse outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23338","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T16:19:57Z","timestamp":1579709997000},"page":"508-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk stratification in patients undergoing interventional left atrial appendage occlusion\u2014Prognostic impact of EuroSCORE II"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-0284","authenticated-orcid":false,"given":"Michael","family":"Gotzmann","sequence":"first","affiliation":[{"name":"Cardiovascular Center, St. Josef Hospital Bochum, Ruhr\u2010University  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinah S.","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Cardiology Marien Hospital Witten, Ruhr University  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Hogeweg","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, St. Josef Hospital Bochum, Ruhr\u2010University  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Heringhaus","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, St. Josef Hospital Bochum, Ruhr\u2010University  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"M\u00fcgge","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, St. Josef Hospital Bochum, Ruhr\u2010University  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Pflaumbaum","sequence":"additional","affiliation":[{"name":"Department of Cardiology Marien Hospital Witten, Ruhr University  Bochum 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