{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:56:27Z","timestamp":1776135387204,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","award":["783454"],"award-info":[{"award-number":["783454"]}],"id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003958","name":"Stichting voor de Technische Wetenschappen","doi-asserted-by":"publisher","award":["91717339"],"award-info":[{"award-number":["91717339"]}],"id":[{"id":"10.13039\/501100003958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The exact pathophysiology of atrial fibrillation (AF) remains incompletely understood and treatment of AF is associated with high recurrence rates. Persistence of AF is rooted in the presence of electropathology, defined as complex electrical conduction disorders caused by structural damage of atrial tissue. The atrial fibrillation fingerprinting (AFFIP) study aims to characterize electropathology, enabling development of a novel diagnostic instrument to predict AF onset and early progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypotheses<\/jats:title><jats:p>History of AF, development of post\u2010operative AF, age, gender, underlying heart disease, and other clinical characteristics impact the degree of electropathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a prospective observational study with a planned duration of 48\u2009months. Three study groups are defined: (1) patients with (longstanding) persistent AF, (2) patients with paroxysmal AF, and (3) patients without a history of AF, all undergoing open\u2010chest cardiac surgery. Intra\u2010operative high\u2010resolution epicardial mapping is performed to identify the patient\u2010specific electrical profile, whereas the patient\u2010specific biological profile is assessed by evaluating proteostasis markers in blood samples and atrial appendage tissue samples. Post\u2010operative continuous rhythm monitoring is performed for detection of early post\u2010operative AF. Late post\u2010operative AF (during 5\u2010year follow\u2010up) is documented by either electrocardiogram or 24\u2010hour Holter registration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The required sample size for this study is estimated at 447 patients. Up till now, 105 patients were included, of whom 36 have a history of AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The AFFIP study will elucidate whether electrophysiological and structural characteristics represent a novel diagnostic tool, the AF fingerprint, to predict onset and early progression of AF in cardiac surgery patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23370","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T07:58:52Z","timestamp":1587196732000},"page":"546-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Atrial fibrillation fingerprinting; spotting bio\u2010electrical markers to early recognize atrial fibrillation by the use of a bottom\u2010up approach (AFFIP): Rationale and design"],"prefix":"10.1002","volume":"43","author":[{"given":"Roeliene","family":"Starreveld","sequence":"first","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Knops","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennedy S.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center  Rotterdam The Netherlands"},{"name":"Department of Physiology, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences  Amsterdam UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten C.","family":"Roos\u2010Serote","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad J.J.C.","family":"Bogers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca J.J.M.","family":"Brundel","sequence":"additional","affiliation":[{"name":"Department of Physiology, Amsterdam UMC Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences  Amsterdam UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0259-6691","authenticated-orcid":false,"given":"Natasja M.S.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.3.229"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31721-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq336"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000342"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.931634"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-013-0481-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.89"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000252323.83137.fe"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006458"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00289-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005300"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09014-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0166-5"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.23370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23370","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T09:55:22Z","timestamp":1693994122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,18]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/clc.23370"],"URL":"https:\/\/doi.org\/10.1002\/clc.23370","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,18]]},"assertion":[{"value":"2020-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}