{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:08Z","timestamp":1786977368053,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several hematological indices including subtypes of leukocytes populations have been associated with cardiovascular outcome. Takotsubo syndrome (TTS) is a form of acute heart failure syndrome featured by several in\u2010hospital complications (IHCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Hematological indices at admission may predict IHCs in TTS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and sixty consecutive patients with TTS were enrolled in a multicenter prospective registry. Clinical data, admission hemogram, and IHCs were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Incidence of IHCs was 37%, including pulmonary edema 9%, cardiogenic shock 9%, need of invasive ventilation 10%, death 8%, stroke 2.5%, and left ventricular thrombi 6%.<\/jats:p>\n                    <jats:p>\n                      Patients with IHCs were older, more frequently male, with physical stressor\u2010induced TTS, lower left ventricular ejection fraction at admission. Neutrophil\/lymphocyte ratio (NLr) (12\u2009\u00b1\u200912 vs 7\u2009\u00b1\u20098,\n                      <jats:italic>P<\/jats:italic>\n                      = .002) and white blood cells\/mean platelet volume ratio (1.2\u2009\u00b1\u20090.5 vs 1.0\u2009\u00b1\u20090.5,\n                      <jats:italic>P<\/jats:italic>\n                      = .03) at admission were significantly higher in patients with IHCs.\n                    <\/jats:p>\n                    <jats:p>\n                      NLr values were predictor of IHCs (Odds ratios [OR] 1.07, 95% CI 1.03\u20101.11,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). When stratified according to NLr into tertiles, the rate of IHCs was from first to third tertile was, respectively, 22%, 31%, and 58%. NLr values in the higher tertile were independent predictors of IHCs even at multivariate analysis (OR 3.7, 95% CI 1.5\u20109.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01).\n                    <\/jats:p>\n                    <jats:p>NLr values higher than 5 were able to predict IHCs with a sensitivity of 82% and specificity of 58%; negative predictive power was 84% (area under the ROC curve 0.73).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NLr is an independent predictor of IHCs in patients admitted with TTS. Admission hemogram may represent a potential tool for prediction of IHCs in TTS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.23442","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T04:58:11Z","timestamp":1596862691000},"page":"1294-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neutrophil\/lymphocyte ratio predicts in\u2010hospital complications in Takotsubo syndrome. 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