{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:45:10Z","timestamp":1747147510109,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Abnormal invasive hemodynamics after transcatheter aortic valve replacement (TAVR) is associated with poor survival; however, the mechanism is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Diastolic dysfunction will modify the association between invasive hemodynamics postTAVR and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with echocardiographic assessment of diastolic function and postTAVR invasive hemodynamic assessment were eligible for the present analysis. Diastology was classified as normal or abnormal (Stages 1 to 3). The aorto\u2010ventricular index (AVi) was calculated as the difference between the aortic diastolic and the left ventricular end\u2010diastolic pressure divided by the heart rate. AVi was categorized as abnormal (AVi\u2009&lt;\u20090.5\u2009mmHg\/beats per minute) or normal (\u2265\u20090.5\u2009mmHg\/beats per minute).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1339 TAVR patients, 390 were included in the final analysis. The mean follow\u2010up was 3.3\u2009\u00b1\u20091.7\u2009years. Diastolic dysfunction was present in 70.9% of the abnormal vs 55.1% of the normal AVi group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). All\u2010cause mortality was 46% in the abnormal vs 31% in the normal AVi group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Adjusted hazard ratio (HR) for AVi\u2009&lt;\u20090.5\u2009mmHg\/beats per minute vs AVi \u22650.5\u2009mmHg\/beats per minute for intermediate\u2010term mortality was (HR = 1.5, 95% confidence interval [CI] 1.1 to 2.1, <jats:italic>P<\/jats:italic> = .017). This association was the same among those with normal diastolic function and those with diastolic dysfunction (<jats:italic>P<\/jats:italic> for interaction = .35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diastolic dysfunction is prevalent among TAVR patients. Low AVi is an independent predictor for poor intermediate\u2010term survival, irrespective of co\u2010morbid diastolic dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23457","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:42:31Z","timestamp":1600821751000},"page":"1428-1434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between baseline diastolic dysfunction and <scp>postimplantation<\/scp> invasive hemodynamics with transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3731-1457","authenticated-orcid":false,"given":"Anthony A.","family":"Bavry","sequence":"first","affiliation":[{"name":"Department of Medicine University of Texas Southwestern  Dallas Texas 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