{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:04:52Z","timestamp":1781129092114,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although successful ablation of the accessory pathway (AP) eliminates atrial fibrillation (AF) in some of patients with Wolff\u2010Parkinson\u2010White (WPW) syndrome and paroxysmal AF, in other patients it can recur.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Whether adding pulmonary vein isolation (PVI) after successful AP ablation effectively prevents AF recurrence in patients with WPW syndrome is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively studied 160 patients (102 men, 58 women; mean age, 46\u2009\u00b1\u200914\u2009years) with WPW syndrome and paroxysmal AF who underwent AP ablation, namely 103 (64.4%) undergoing only AP ablation (AP group) and 57 (35.6%) undergoing AP ablation plus PVI (AP\u2009+\u2009PVI group). Advanced interatrial block (IAB) was defined as a P\u2010wave duration of &gt;120\u2009ms and biphasic (\u00b1) morphology in the inferior leads, using 12\u2010lead electrocardiography (ECG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the mean follow\u2010up period of 30.9\u2009\u00b1\u20099.2 months (range, 3\u201036\u2009months), 22 patients (13.8%) developed AF recurrence. The recurrence rate did not differ in patients in the AP\u2009+\u2009PVI group and AP group (15.5% vs 10.5%, respectively; <jats:italic>P<\/jats:italic> = .373). Univariable and multivariable Cox regression analyses showed that PVI was not associated with the risk of AF recurrence (hazard ratio, 0.66; 95% confidence interval, 0.26\u20101.68; <jats:italic>P<\/jats:italic> = .380). In WPW patients with advanced IAB, the recurrence rate was lower in patients in the AP\u2009+\u2009PVI group vs the AP group (90% vs 33.3%, respectively; <jats:italic>P<\/jats:italic> = .032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PVI after successful AP ablation significantly reduced the AF recurrence rate in WPW patients with advanced IAB. Screening of a resting 12\u2010lead ECG immediately after AP ablation helps identify patients in whom PVI is beneficial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23470","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T17:25:53Z","timestamp":1601573153000},"page":"1511-1516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of pulmonary vein isolation on atrial fibrillation recurrence after accessory pathway ablation in patients with <scp>Wolff\u2010Parkinson\u2010White<\/scp> syndrome"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-6920","authenticated-orcid":false,"given":"Jin\u2010Tao","family":"Wu","sequence":"first","affiliation":[{"name":"Heart Centre of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou 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Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Wei","family":"Fan","sequence":"additional","affiliation":[{"name":"Heart Centre of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Ling","family":"Hu","sequence":"additional","affiliation":[{"name":"Heart Centre of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"Heart Centre of Henan Provincial People's Hospital, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University  Zhengzhou 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