{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:17:19Z","timestamp":1777529839920,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac injury is common in COVID\u201019 patients and is associated with increased mortality. However, it remains unclear if reduced cardiac function is associated with cardiac injury, and additionally if mortality risk is increased among those with reduced cardiac function in COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The aim of this study was to assess cardiac function among COVID\u201019 patients with and without biomarkers of cardiac injury and to determine the mortality risk associated with reduced cardiac function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Results<\/jats:title><jats:p>This retrospective cohort study analyzed 143 consecutive COVID\u201019 patients who had an echocardiogram during hospitalization between March 1, 2020 and May 5, 2020. The mean age was 67\u2009\u00b1\u200916\u2009years. Cardiac troponin\u2010I was available in 131 patients and an increased value (&gt;0.03\u2009ng\/dL) was found in 59 patients (45%). Reduced cardiac function, which included reduced left or right ventricular systolic function, was found in 40 patients (28%). Reduced cardiac function was found in 18% of patients without troponin\u2010I elevation, 42% with mild troponin increase (0.04\u20105.00\u2009ng\/dL) and 67% with significant troponin increase (&gt;5 ng\/dL). Reduced cardiac function was also present in more than half of the patients on mechanical ventilation or those deceased. The in\u2010hospital mortality of this cohort was 28% (N = 40). Using logistic regression analysis, we found that reduced cardiac function was associated with increased mortality with adjusted odds ratio (95% confidence interval) of 2.65 (1.18 to 5.96).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reduced cardiac function is highly prevalent among hospitalized COVID\u201019 patients with biomarkers of myocardial injury and is independently associated with mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23479","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T11:51:42Z","timestamp":1602676302000},"page":"1547-1554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reduced cardiac function is associated with cardiac injury and mortality risk in hospitalized <scp>COVID<\/scp>\u201019 Patients"],"prefix":"10.1002","volume":"43","author":[{"given":"Lu Q.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Research and Department of Cardiology St Francis Hospital, The Heart Center  Roslyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Burdowski","sequence":"additional","affiliation":[{"name":"Department of Research and Department of Cardiology St Francis Hospital, The Heart Center  Roslyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0812-7722","authenticated-orcid":false,"given":"Ravi","family":"Marfatia","sequence":"additional","affiliation":[{"name":"Department of Research and Department of Cardiology St Francis Hospital, The Heart Center  Roslyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6847-8057","authenticated-orcid":false,"given":"Jonathan","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Research 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