{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:29:14Z","timestamp":1787066954596,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["838259"],"award-info":[{"award-number":["838259"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coronary artery disease (CAD) is a significant risk factor for atrial fibrillation (AF). Experimental studies demonstrated that atrial ischemia induced by right coronary artery (RCA) stenosis promote AF triggers and development of electro\u2010anatomical substrate for AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyze the association between AF prevalence and coronary arteries status in the LIFE\u2010Heart Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This analysis included patients with available coronary catheterization data recruited between 2006 and 2014. Patients with acute myocardial infarction were excluded. CAD was defined as stenosis \u226575%, while coronary artery sclerosis (CAS) was defined as non\u2010critical plaque(s) &lt;75%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 3.458 patients (median age 63\u2009years, 34% women) were included into analysis. AF was diagnosed in 238 (6.7%) patients. There were 681 (19.7%) patients with CAS and 1.411 (40.8%) with CAD (27.5% with single, 32.4% with double, and 40.1% with triple vessel CAD). In multivariable analysis, there was a significant association between prevalent AF and coronary artery status (OR 0.64, 95% CI 0.53\u20100.78,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      \u2009&lt;\u2009.001). Similarly, AF risk was lower in patients with higher CAD extent (OR 0.54, 95%CI 0.35\u20100.83,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      = .005). Compared to single vessel CAD, the risk of AF was lower in double (OR 0.42, 95%CI 0.19\u20100.95,\n                      <jats:italic>P<\/jats:italic>\n                      = .037) and triple CAD (OR 0.31, 95%CI 0.13\u20100.71,\n                      <jats:italic>P<\/jats:italic>\n                      = .006). Finally, no association was found between AF prevalence and CAD origin among patients with single vessel CAD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the LIFE\u2010Heart Study, CAS but not CAD was associated with increased risk of AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.23490","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T05:47:21Z","timestamp":1603777641000},"page":"1616-1623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of atrial fibrillation dependent on coronary artery status: Insights from the\n                    <scp>LIFE\u2010Heart<\/scp>\n                    Study"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3551-1145","authenticated-orcid":false,"given":"Jelena","family":"Kornej","sequence":"first","affiliation":[{"name":"National Heart, Lung, and Blood Institute's Framingham Heart Study Framingham Massachusetts USA"},{"name":"Sections of Cardiovascular Medicine and Preventive Medicine, Boston Medical Center Boston University School of Medicine Boston Massachusetts USA"},{"name":"LIFE \u2013 Leipzig Research Center of Civilization Diseases Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Henger","sequence":"additional","affiliation":[{"name":"LIFE \u2013 Leipzig Research Center of Civilization Diseases Leipzig University Leipzig Germany"},{"name":"Institute for Medical Informatics, Statistics and Epidemiology Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-6779","authenticated-orcid":false,"given":"Timm","family":"Seew\u00f6ster","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart Center at University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Teren","sequence":"additional","affiliation":[{"name":"LIFE \u2013 Leipzig Research Center of Civilization Diseases Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"LIFE \u2013 Leipzig Research Center of Civilization Diseases Leipzig University Leipzig Germany"},{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology Heart Center at University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Thiery","sequence":"additional","affiliation":[{"name":"LIFE \u2013 Leipzig Research Center of Civilization Diseases Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Scholz","sequence":"additional","affiliation":[{"name":"LIFE \u2013 Leipzig Research Center of Civilization Diseases Leipzig University Leipzig Germany"},{"name":"Institute for Medical Informatics, Statistics and Epidemiology Leipzig University Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.15.1861"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.972778"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.4.1-2.17"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.01.018"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000058743.15215.03"},{"key":"e_1_2_11_9_1","first-page":"H47","article-title":"Vulnerability of rabbit atrium to reentry by hypoxia. Role of inhomogeneity in conduction and wavelength","volume":"262","author":"Lammers WJ","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.3760\/cma.j.issn.0366-6999.20123413","article-title":"Impact of the origin of sinus node artery on recurrence after pulmonary vein isolation in patients with paroxysmal atrial fibrillation","volume":"126","author":"Zhang ZJ","year":"2013","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes144"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.12.039"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa075"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029070"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.7.2455"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.17.1.90"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-009-0081-y"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23490","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T09:36:09Z","timestamp":1723800969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/clc.23490"],"URL":"https:\/\/doi.org\/10.1002\/clc.23490","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"assertion":[{"value":"2020-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}