{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:29:32Z","timestamp":1773815372745,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Enhanced external counterpulsation (EECP) is a noninvasive treatment that can decrease limiting symptoms in patients with refractory angina pectoris (RAP). Identifying responders to EECP is important as EECP is not widely available and relatively time intensive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The effect of EECP treatment on physical capacity in patients with RAP can be predicted from baseline patient characteristics and clinical factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This explorative study includes all patients from a cardiology clinic who had finished one EECP treatment and a 6\u2009min walk test pre and post EECP. Clinical data, including Canadian Cardiovascular Society (CCS) classification and left ventricular ejection fraction (LVEF), were assessed before treatment. If patients increased their 6\u2009min walking distance (6MWD) by 10% post EECP, they were considered responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 119 patients (men = 97, 40\u201391\u2009years), 49 (41.2%) were responders. Multinomial regression analysis showed that functional status (i.e., CCS class \u22653) (OR 3.10, 95% CI 1.12\u20138.57), LVEF &lt;50% (OR 2.82, 95% CI 1.02\u20137.80), and prior performed revascularization (i.e., \u2264\u20091 type of intervention) (OR 2.77, 95% CI 1.06\u20137.20) were predictors of response to EECP (p\u2009&lt;\u2009.05, Accuracy 63.6%). Traditional risk factors (e.g., gender, smoking, and comorbidities) did not predict response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EECP treatment should be considered preferentially for patients that have a greater functional impairment, evidence of systolic left ventricular dysfunction, and exposure to fewer types of revascularization, either PCI or CABG. Improvement in 6MWD post EECP could imply improvement in physical capacity, which is a likely contributor to improved well\u2010being among patients with RAP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23516","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T07:35:55Z","timestamp":1609918555000},"page":"160-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Predictors of treatment benefits after enhanced external counterpulsation in patients with refractory angina pectoris"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-7541","authenticated-orcid":false,"given":"Eline","family":"Wu","sequence":"first","affiliation":[{"name":"School of Health and Welfare J\u00f6nk\u00f6ping University  J\u00f6nk\u00f6ping Sweden"},{"name":"Heart and Vascular Theme Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"M\u00e5rtensson","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Health and Welfare J\u00f6nk\u00f6ping University  J\u00f6nk\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyew","family":"Desta","sequence":"additional","affiliation":[{"name":"Heart and Vascular Theme Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Medicine, Division of Cardiology Karolinska Institute  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Brostr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Health and Welfare J\u00f6nk\u00f6ping University  J\u00f6nk\u00f6ping Sweden"},{"name":"Department of Clinical Neurophysiology Link\u00f6ping University Hospital  Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000095"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2016:26:1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.08.055"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.200"},{"key":"e_1_2_9_7_1","first-page":"9","article-title":"Prevalence of refractory angina in clinical practice","volume":"72","author":"Gowdak LHW","year":"2017","journal-title":"Heart Metab"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-51510200047-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319711399897"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0000000000000530"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047041.66447.29"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000122"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2014.04.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2013.1169"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00140-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-8-39"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20117"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474515112468067"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000057"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0000000000000638"},{"issue":"14","key":"e_1_2_9_21_1","first-page":"1096","article-title":"Six\u2010minute walk test as a prognostic tool in patients with stable coronary heart disease: data from the heart and soul study","volume":"172","author":"Beatty AL","year":"2012","journal-title":"Intern Med"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(02)00244-1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.09.005"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01880.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002002"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20766"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"issue":"8","key":"e_1_2_9_28_1","first-page":"783","article-title":"The six\u2010minute walk test","volume":"48","author":"Enright PL","year":"2003","journal-title":"Respir Care"},{"key":"e_1_2_9_29_1","unstructured":"The World Medical Association (WMA).WMA declaration of Helsinki \u2013 ethical principles for medical research involving human subjects. 64th WMA General Assembly Fortaleza Brazil October 2013. Available online 17 January 2020:https:\/\/www.wma.net\/policies-post\/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects\/"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001646"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085170"},{"key":"e_1_2_9_32_1","first-page":"ii7","article-title":"Epidemiology and management of heart failure and left ventricular systolic dysfunction in the aftermath of myocardial infarction","volume":"91","author":"Cleland JGF","year":"2005","journal-title":"Heart"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.416"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-315042"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12097"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X14666180222102312"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2014.994028"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474515112472271"}],"updated-by":[{"DOI":"10.1002\/clc.23751","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000}}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T13:48:58Z","timestamp":1693662538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/clc.23516"],"URL":"https:\/\/doi.org\/10.1002\/clc.23516","archive":["Portico"],"relation":{"erratum":[{"id-type":"doi","id":"10.1002\/clc.23751","asserted-by":"object"}]},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"2020-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}