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PCI is associated with unplanned readmission for angina and non\u2010specific chest pain within 30\u2010days of index PCI. Patients with an index hospitalization for PCI between January\u2013November in each of the years 2010\u20132014 were included from the United States Nationwide Readmissions Database. Of 2\u2009723\u2009455 included patients, the 30\u2010day unplanned readmission rate was 7.2% (<jats:italic>n<\/jats:italic> = 196\u2009581, 42.3% female). This included 9.8% (<jats:italic>n<\/jats:italic> = 19\u2009183) with angina and 11.1% (<jats:italic>n<\/jats:italic> = 21\u2009714) with non\u2010specific chest pain. The unplanned readmission group were younger (62.2 vs 65.1\u2009years; <jats:italic>P<\/jats:italic> &lt;\u20090.001), more likely to be females (41.0% vs 34.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), from the lowest quartile of household income (32.9% vs 31.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), have higher prevalence of cardiovascular risk factors or have index PCI performed for non\u2010acute coronary syndromes (ACS) (OR:3.46, 95%CI 3.39\u20133.54). Factors associated with angina readmissions included female sex (OR:1.28, 95%CI 1.25\u20131.32), history of ischemic heart disease (IHD) (OR:3.28, 95%CI 2.95\u20133.66), coronary artery bypass grafts (OR:1.79, 95%CI 1.72\u20132.86), anaemia (OR:1.16, 95%CI 1.11\u20131.21), hypertension (OR:1.13, 95%CI 1.09, 1.17), and dyslipidemia (OR:1.10, 95%CI 1.06\u20131.14). Non\u2010specific chest pain compared with angina readmissions were younger (mean difference 1.25\u2009years, 95% CI 0.99, 1.50), more likely to be females (RR:1.13, 95%CI 1.10, 1.15) and have undergone PCI for non\u2010ACS (RR:2.17, 95%CI 2.13, 2.21). Indications for PCI other than ACS have a greater likelihood of readmission with angina or non\u2010specific chest pain at 30\u2010days. Readmissions are more common in patients with modifiable risk factors, previous history of IHD and anaemia.<\/jats:p>","DOI":"10.1002\/clc.23543","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T05:01:34Z","timestamp":1613710894000},"page":"291-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Percutaneous coronary intervention and <scp>30\u2010day<\/scp> unplanned readmission with chest pain in the United States (Nationwide Readmissions Database)"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-5474","authenticated-orcid":false,"given":"RobertA.","family":"Sykes","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow  Glasgow UK"},{"name":"Golden Jubilee National Hospital  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed O.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Keele University  Keele Staffordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Shing","family":"Kwok","sequence":"additional","affiliation":[{"name":"Keele University  Keele Staffordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele University  Keele Staffordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-8636","authenticated-orcid":false,"given":"Colin","family":"Berry","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow  Glasgow UK"},{"name":"Golden Jubilee National Hospital  UK"},{"name":"Royal Stoke University Hospital  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505532"},{"key":"e_1_2_9_3_1","first-page":"31","article-title":"Percutaneous coronary intervention in stable angina (ORBITA): a double\u2010blind","volume":"391","author":"Al\u2010Lamee R","year":"2018","journal-title":"Randomised Controlled Trial Lancet"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32283-9"},{"key":"e_1_2_9_5_1","first-page":"375","article-title":"Readmissions to hospital after percutaneous coronary intervention: a systematic review and meta\u2010analysis of factors associated with readmissions","volume":"21","author":"Kwok CS","year":"2020","journal-title":"Cardiovascular Res Med"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.050"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.12.032"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.02.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.01.248"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.034"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy857"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.21322"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024534"},{"key":"e_1_2_9_15_1","first-page":"e008126","article-title":"Ischemia and no obstructive coronary artery disease prevalence and correlates of coronary Vasomotion disorders. 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