{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:06:53Z","timestamp":1768450013330,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The significance of left atrial volume index (LAVI) for predicting outcomes in patients with mitral stenosis (MS) has been unclear, even though rheumatic MS is known to be associated with left atrium enlargement and functional deterioration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The current study aimed to investigate the prognostic value of LAVI, based on the severity in patients with rheumatic MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed 611 patients with pure rheumatic MS. The prognostic value of LAVI and the effect of MS severity on the prognostic value of LAVI for events were evaluated. The events were defined as a composite end\u2010point that included all\u2010cause death, heart failure admission, mitral valve replacement, percutaneous mitral valvuloplasty, and stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 236 (38.6%) overall events during a median follow\u2010up of 8 months. The optimal LAVI cutoff for the prognostic threshold was 57\u2009ml\/m<jats:sup>2<\/jats:sup>. The MS severity had a significant effect on the prognostic value of LAVI. A LAVI &gt;57\u2009ml\/m<jats:sup>2<\/jats:sup> was a prognostic value for events in progressive MS (hazard ratio [HR]: 2.40, 95% confidence interval [CI]: 1.41\u20135.40, <jats:italic>p<\/jats:italic> = .004) and in patients with severe MS (HR: 1.70, 95% CI: 1.06\u20132.74, <jats:italic>p<\/jats:italic> = .029), but it was not prognostic in patients with very severe MS (HR: 1.02, 95% CI: 0.56\u20131.84, <jats:italic>p<\/jats:italic> = .955).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prognostic value of LAVI varies and is dependent on the MS severity. A LAVI &gt;57\u2009mL\/m<jats:sup>2<\/jats:sup> was independently associated with poor outcomes in patients with progressive MS, while this association was minimized in patients with severe MS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23544","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T04:35:39Z","timestamp":1610080539000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic value of left atrial volume index in patients with rheumatic mitral stenosis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-5129","authenticated-orcid":false,"given":"In\u2010Jeong","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Ewha Womans University Seoul Hospital, College of Medicine, Ewha Womans University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeonju","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Myungji Hospital  Goyang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-7545","authenticated-orcid":false,"given":"Hyuk\u2010Jae","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Severance Cardiovascular Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2010.10.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.09.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000066318.21784.43"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.054"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.059"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.23"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006615"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01019-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.04.057"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12756"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.055"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.11.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4250\/jcvi.2019.27.e20"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.537"},{"issue":"7","key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"685\u2013713; quiz 7","DOI":"10.1016\/j.echo.2010.05.010","article-title":"Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography","volume":"23","author":"Rudski LG","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/1995-705X.99227"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.09.076"},{"issue":"2","key":"e_1_2_8_20_1","first-page":"S242\u2013247","article-title":"Left atrial performance indices in chronic mitral valve disease","volume":"4","author":"Boudoulas H","year":"1995","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.110284"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.67.1.148"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.03.012"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010736"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23544","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T09:52:56Z","timestamp":1693648376000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,6]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/clc.23544"],"URL":"https:\/\/doi.org\/10.1002\/clc.23544","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,6]]},"assertion":[{"value":"2020-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}