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A very serious yet underrecognized form of this disease is cardiac amyloidosis, in which amyloid deposits into the extracellular space of the myocardium, resulting in thickening and stiffening of ventricular walls with resultant heart failure and conductive dysfunction. This review provides a discussion of the pathogenesis and clinical presentation of cardiac amyloidosis subtypes, as well as an up\u2010to\u2010date approach to diagnosis and treatment. Significant progress has been made in recent years regarding diagnosis and treatment of this condition, but prognosis remains heavily reliant on early detection of the disease. Two types of precursor protein are responsible for most cardiac amyloidosis cases: transthyretin amyloid, and immunoglobulin\u2010derived light chain amyloid. An early diagnosis of cardiac amyloidosis can allow for novel treatment modalities to be initiated with the potential to improve prognosis.<\/jats:p>","DOI":"10.1002\/clc.23572","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T08:33:15Z","timestamp":1613809995000},"page":"322-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Cardiac amyloidosis\u2010A review of current literature for the practicing physician"],"prefix":"10.1002","volume":"44","author":[{"given":"Samantha","family":"Ash","sequence":"first","affiliation":[{"name":"Dept of Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Shorer","sequence":"additional","affiliation":[{"name":"Dept of Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1271-7880","authenticated-orcid":false,"given":"Devyani","family":"Ramgobin","sequence":"additional","affiliation":[{"name":"Dept of Medicine Touro College of Osteopathic Medicine  Middletown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maique","family":"Vo","sequence":"additional","affiliation":[{"name":"Dept of Medicine Touro College of Osteopathic Medicine  Middletown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Dept of Medicine Touro College of Osteopathic Medicine  Middletown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma","family":"Golamari","sequence":"additional","affiliation":[{"name":"Dept of Medicine Penn State Milton S Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Jain","sequence":"additional","affiliation":[{"name":"Dept of Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Jain","sequence":"additional","affiliation":[{"name":"Dept of Medicine Penn State Milton S Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-2-s30"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701206887"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.053"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.190405"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000792"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2015.07.008"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.075"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-017-0607-4"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.596"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2017.04.003"},{"issue":"2","key":"e_1_2_13_12_1","first-page":"178","article-title":"Amyloid heart disease. 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