{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:24:11Z","timestamp":1780759451985,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:00:00Z","timestamp":1620432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>SARS\u2010CoV2 has affected more than 73.8 million individuals. While SARS\u2010CoV2 is considered a predominantly respiratory virus, we report a trend of bradycardia among hospitalized patients, particularly in association with mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>The multi\u2010center retrospective analysis consisted of 1053 COVID\u201019 positive patients from March to August 2020. A trend of bradycardia was noted in the study population. Absolute bradycardia and profound bradycardia was defined as a sustained heart rate\u2009&lt;\u200960 BPM and\u2009&lt;\u200950 BPM, respectively, on two separate occasions, a minimum of 4\u2009h apart during hospitalization. Each bradycardic event was confirmed by two physicians and exclusion criteria included: less than 18\u2009years old, end of life bradycardia, left AMA, or taking AV Nodal blockers. Data was fetched using a SQL program through the EMR and data was analyzed using SPSS 27.0. A logistic regression was done to study the effect of bradycardia, age, gender, and BMI on mortality in the study group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>24.9% patients had absolute bradycardia while 13.0% had profound bradycardia. Patients with absolute bradycardia had an odds ratio of 6.59 (95% CI [2.83\u201315.36]) for mortality compared with individuals with a normal HR response. The logistic regression model explained 19.6% (Nagelkerke R<jats:sup>2<\/jats:sup>) of variance in the mortality, correctly classified 88.6% of cases, and was statistically significant X<jats:sup>2<\/jats:sup> (5)=47.10, p\u2009&lt;\u2009.001. For each year of age\u2009&gt;\u200918, the odds of dying increased 1.048 times (95% CI [1.25\u20135.27]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of absolute bradycardia was found in 24.9% of the study cohort and these individuals were found to have a significant increase in mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23622","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T07:26:33Z","timestamp":1620545193000},"page":"857-862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A novel study on SARS\u2010COV\u20102 virus associated bradycardia as a predictor of mortality\u2010retrospective multicenter analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3851-9142","authenticated-orcid":false,"given":"Sabina","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hemet Global Medical Center  Hemet California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Arcuri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hemet Global Medical Center  Hemet California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanta","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hemet Global Medical Center  Hemet California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-2854","authenticated-orcid":false,"given":"Rahul","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hemet Global Medical Center  Hemet California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Aseri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hemet Global Medical Center  Hemet California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Barve","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hemet Global Medical Center  Hemet California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivang","family":"Shah","sequence":"additional","affiliation":[{"name":"Divison of Cardiology Loma Linda University School of Medicine  Loma Linda California USA"},{"name":"Division of Cardiology University of California Riverside School of Medicine  Riverside California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2020.107"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.06.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-020-00789-9"},{"issue":"6","key":"e_1_2_8_6_1","first-page":"e8599","article-title":"Bradycardia in patients with COVID\u201019: a calm before the storm?","volume":"12","author":"Amaratunga EA","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2020.08.025"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2020.07.015"},{"issue":"20","key":"e_1_2_8_9_1","first-page":"30495","article-title":"Relative bradycardia in patients with COVID\u201019 [published online ahead of print, 2020 Aug 18]","volume":"1198","author":"Capoferri G","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(82)90634-3"},{"issue":"10","key":"e_1_2_8_11_1","article-title":"Angiotensin\u2010Converting Enzyme 2 (ACE2): SARS\u2010CoV\u20102 Receptor and RAS Modulator","volume":"126","author":"Bian J","year":"2020","journal-title":"Acta Pharmaceutica Sinica B"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"73","article-title":"The clinical significance of relative bradycardia","volume":"117","author":"Ye F","year":"2018","journal-title":"WMJ"},{"key":"e_1_2_8_13_1","unstructured":"The European Society for Cardiology. ESC Guidance for the Diagnosis and Management of CV Disease during the COVID\u201019 Pandemic.https:\/\/www.escardio.org\/Education\/COVID\u201019\u2010and\u2010Cardiology\/ESC\u2010COVID\u201019\u2010Guidance."},{"key":"e_1_2_8_14_1","first-page":"336","article-title":"ANMCO position paper: guidance for the management of suspected or confirmed COVID\u201019 patients requiring urgent electrophysiological procedures","volume":"5","author":"Gulizia MM","year":"2020","journal-title":"G Ital Cardiol"},{"key":"e_1_2_8_15_1","first-page":"27","article-title":"Cardiac involvement in a patient with coronavirus disease 2019 (COVID\u201019)","author":"Inciardi RM","year":"2020","journal-title":"JAMA Cardiol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2005.037515"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23622","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:45:18Z","timestamp":1693291518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,8]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/clc.23622"],"URL":"https:\/\/doi.org\/10.1002\/clc.23622","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,8]]},"assertion":[{"value":"2021-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}