{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:59:57Z","timestamp":1791403197105,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Central retinal artery occlusion ((C)RAO) is known to be associated with stroke and\/or atrial fibrillation (AF). Nevertheless, patients often present at the ophthalmologist initially and it is unknown how many of these receive an adequate cardiological\/neurological work\u2010up (CWU\/NWU), including a 24\u2009h\u2010Holter\u2010ECG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Hypothesis of this study was that patients with (C)RAO do not undergo CWU on regular basis and that new\u2010onset AF is more often detected in patients with CWU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We performed a retrospective analysis of <jats:italic>n<\/jats:italic>\u00a0=\u2009292 consecutive patients who presented at an ophthalmology department with the diagnosis of (C)RAO during a 3\u2010year period. After excluding patients with known AF, meeting exclusion criteria, inability to comply with the protocol, missed land phoneline, or death during follow\u2010up a total of 174 patients were enrolled; mean follow\u2010up was 20 \u00b1 12\u2009months. The CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score of the cohort was 5.3\u00a0\u00b1\u20091.4. Our analysis revealed that only 50.6% of patients received a CWU including a single Holter\u2010ECG after the index\u2010event. In 12.6% cases new\u2010onset AF was diagnosed, while the rate was higher in patients with CWU compared to patients without CWU (18.2 vs. 7.0%; <jats:italic>p<\/jats:italic>\u00a0=\u20090.26). Evaluation of oral anticoagulation (OAC) therapy showed that only 66% of patients with AF were treated according to guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Only half of patients with (C)RAO underwent CWU. Despite minimal monitoring, rate of new diagnosed AF was high. Our results confirm that (C)RAO identifies a high\u2010risk population for AF. These results illustrate the importance to implement standardized CWU in (C)RAO patients presenting at the ophthalmologist.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23673","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T07:40:19Z","timestamp":1635406819000},"page":"1654-1661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Central retinal artery occlusion as a first sign of atrial fibrillation: A 3\u2010year retrospective single\u2010center analysis"],"prefix":"10.1002","volume":"44","author":[{"given":"Nadine","family":"Vonderlin","sequence":"first","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, West\u2010German Heart and Vascular Center Essen University of Essen Medical School, University Duisburg\u2010Essen  Essen Germany"},{"name":"Medical Clinic I University of Munich  Munich Germany"},{"name":"German Centre for Cardiovascular Research (DZHK)  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