{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:44:08Z","timestamp":1788457448792,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recurrence rates of atrial fibrillation (AF) after pulmonary vein isolation (PVI) are higher in patients with a left atrial low\u2010voltage area (LVA) than those without. However, the efficacy of LVA guided ablation is still unknown. The purpose of this study\u2014the Efficacy and Safety of Left Atrial Low\u2010voltage Area Guided Ablation for Recurrence Prevention Compared to Pulmonary Vein Isolation Alone in Patients with Persistent Atrial Fibrillation trial (SUPPRESS\u2010AF trial)\u2014is to elucidate whether LVA guided ablation in addition to PVI is superior to PVI alone in patients with persistent AF. The Osaka Cardiovascular Conference will conduct a multicenter, randomized, open\u2010label trial aiming to examine whether LVA guided ablation in addition to PVI is superior to PVI alone in patients with persistent AF and LVAs. The primary outcome is the recurrence of AF documented by scheduled or symptom\u2010driven electrocardiography (ECG) during the 1\u00a0year follow\u2010up period after the index ablation. The key secondary endpoints include all\u2010cause death, symptomatic stroke, bleeding events, and other complications related to the procedure. A total of 340 patients with an LVA will be enrolled and followed up to 1\u00a0year. The SUPPRESS\u2010AF trial is a randomized controlled trial designed to assess whether LVA guided ablation in addition to PVI is superior to PVI alone for patients with persistent AF and LVAs detected while undergoing their first catheter ablation.<\/jats:p>","DOI":"10.1002\/clc.23677","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T07:40:50Z","timestamp":1626939650000},"page":"1249-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The efficacy and safety of left atrial low\u2010voltage area guided ablation for recurrence prevention compared to pulmonary vein isolation alone in patients with persistent atrial fibrillation trial: Design and rationale"],"prefix":"10.1002","volume":"44","author":[{"given":"Akihiro","family":"Sunaga","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine  Suita 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