{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:34:24Z","timestamp":1787718864696,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was primarily to determine efficacy after alcohol septal ablation (ASA) in mildly symptomatic patients (NYHA class II) with hypertrophic obstructive cardiomyopathy (HOCM), as compared to medical therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 163 mildly symptomatic patients with HOCM evaluated in Beijing Anzhen Hospital between March 2001 and August 2019, consisting of the medical group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0105) and the ASA group (<jats:italic>n<\/jats:italic>\u00a0=\u00a058). All\u2010cause mortality and HCM\u2010related death were mainly observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow\u2010up was completed in 161 patients and the median follow\u2010up was 6.0\u2009years. Compared to medically treated patients, patients post\u2010ASA had comparable survival free of all\u2010cause mortality (98.3% and 95.1% vs. 93.0% and 83.1% at 5 and 10\u2009years, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.374). Survival free of HCM\u2010related death was also similar between ASA and medical groups (98.3% and 95.1% vs. 94.3% and 86.2% at 5 and 10\u2009years, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.608). However, compared to medical therapy, ASA had advantages on the improvement of NYHA class (1.4\u2009\u00b1\u20090.6 vs. 2.1\u2009\u00b1\u20090.5, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000) and lower occurrence of new\u2010onset atrial fibrillation (AF) (7.8% vs. 20.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.048). Multivariate analysis demonstrated that resting LVOT gradient at the last clinical check\u2010up was an independent predictor of all\u2010cause mortality (HR\u00a0=\u00a01.021, 95%CI 1.002\u20131.040, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This registry suggests that mildly symptomatic patients with HOCM treated with ASA have comparable survival to that of medically treated patients, with the improvement of NYHA class and lower occurrence of new\u2010onset AF. All\u2010cause mortality is independently associated with resting LVOT gradient at the last clinical check\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23697","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T11:02:13Z","timestamp":1627124533000},"page":"1409-1415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcome of alcohol septal ablation in mildly symptomatic patients with hypertrophic obstructive cardiomyopathy: A comparison with medical therapy"],"prefix":"10.1002","volume":"44","author":[{"given":"Peijin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguo","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianpeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengyong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3011-0206","authenticated-orcid":false,"given":"Jiqiang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,24]]},"reference":[{"issue":"20","key":"e_1_2_9_2_1","first-page":"1977","article-title":"Clinical course and management of hypertrophic cardiomyopathy","volume":"379","author":"Maron BJ","year":"2018","journal-title":"N Engl J Med"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"47","article-title":"Hypertrophic obstructive cardiomyopathy","volume":"116","author":"Batzner A","year":"2019","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31321-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.076257"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht495"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv693"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.01.079"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90160-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.841"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91267-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.17.1750"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.064"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005735"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029267"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy064"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2017.01.027"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-018-9752-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.18-438"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309699"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.06.012"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.06.011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.862359"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23697","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:35:49Z","timestamp":1693352149000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,24]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/clc.23697"],"URL":"https:\/\/doi.org\/10.1002\/clc.23697","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,24]]},"assertion":[{"value":"2021-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}