{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:51:10Z","timestamp":1793044270610,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Left atrial appendage (LAA) thrombus in patients with atrial fibrillation is usually detected by transesophageal echocardiography (TEE). Intracardiac echocardiography (ICE) can be a suitable alternative to detect thrombosis. However, the effectiveness of the two methods for detecting LAA thrombus is still unclear, we performed a meta\u2010analysis that compared ICE versus TEE for LAA thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Cochrane Library, and Embase for published abstracts and manuscripts on June 1, 2020. The analysis was performed using RevMan 5.3, STATA 15, and Meta\u2010Disc 1.4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight studies consists of 1108 patients (TEE\u00a0=\u00a0558 vs. ICE\u00a0=\u00a0550) were included. The average sensitivity of ICE and TEE to diagnose LAA thrombus is 1.0 (95% CI: 0.91\u20131.00) versus 0.68 (95% CI: 0.49\u20130.83), and specificity of ICE and TEE to diagnosis of LAA thrombus is 1.0 (95% CI: 0.99\u20131.00) versus 0.98 (95% CI: 0.96\u20130.99). The AUC of ICE and TEE is 0.9846 (SEAUC\u00a0=\u00a00.0196) and 0.9655 (SEAUC\u00a0=\u00a00.0401), and the Q* statistics is 0.9462 (SEQ*\u00a0=\u00a00.0406) and 0.9127 (SEQ *\u00a0=\u00a00.0616), respectively. Z test was performed on Q* statistics (Z\u00a0=\u00a00.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ICE and TEE have similar diagnostic efficacy for LAA thrombosis, but the ICE has higher sensitivity. Compared with TEE, ICE may be more advantages and prospects for clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.23698","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T02:40:46Z","timestamp":1630723246000},"page":"1416-1421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Intracardiac versus transesophageal echocardiography for diagnosis of left atrial appendage thrombosis in atrial fibrillation: A meta\u2010analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-126X","authenticated-orcid":false,"given":"Guijun","family":"He","sequence":"first","affiliation":[{"name":"Chengdu Third People's Hospital, Chengdu Institute of Cardiovascular Diseases  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxion","family":"Liu","sequence":"additional","affiliation":[{"name":"Chengdu Third People's Hospital, Chengdu Institute of Cardiovascular Diseases  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Fourth People's Hospital of Chengdu  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Deng","sequence":"additional","affiliation":[{"name":"Chengdu Third People's Hospital, Chengdu Institute of Cardiovascular Diseases  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosu","family":"Yang","sequence":"additional","affiliation":[{"name":"Chengdu Third People's Hospital, Chengdu Institute of Cardiovascular Diseases  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan","family":"Luo","sequence":"additional","affiliation":[{"name":"Chengdu Third People's Hospital, Chengdu Institute of Cardiovascular Diseases  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cai","sequence":"additional","affiliation":[{"name":"Chengdu Third People's Hospital, Chengdu Institute of Cardiovascular Diseases  Chengdu 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echocardiography for verification for left atrial appendage thrombus presence detected by transesophageal echocardiography: the ActionICE II study","author":"Baran J","year":"2017","journal-title":"Clin Cardiol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-0077"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERP-18-0083"},{"issue":"11","key":"e_1_2_9_15_1","first-page":"797","article-title":"Usefulness of multiplane transesophageal echocardiography in the recognition of artifacts and normal anatomical variants that may mimic left atrial thrombi in patients with atrial fibrillation","volume":"4","author":"Maltagliati A","year":"2003","journal-title":"Ital Heart J"},{"key":"e_1_2_9_16_1","article-title":"Advantages of the integration of ICE and 3D electroanatomical mapping and ultrasound\u2010guided femoral venipuncture in catheter ablation of atrial fibrillation","author":"Greca L","year":"2020","journal-title":"J Interv Card Electrophysiol"},{"key":"e_1_2_9_17_1","first-page":"635","article-title":"Predictors of cardiac perforation with catheter ablation of atrial fibrillation","volume":"6","author":"Friedman DJ","year":"2020","journal-title":"J Am Coll Cardiol EP"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-019-00677-x"}],"container-title":["Clinical 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