{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:58:00Z","timestamp":1778219880135,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017007","name":"Adelson Family Foundation","doi-asserted-by":"publisher","award":["Donor funded. No grant number associated"],"award-info":[{"award-number":["Donor funded. No grant number associated"]}],"id":[{"id":"10.13039\/100017007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000064"],"award-info":[{"award-number":["UL1TR000064"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009821","name":"SWHR","doi-asserted-by":"publisher","award":["Donor funded. No grant number associated"],"award-info":[{"award-number":["Donor funded. No grant number associated"]}],"id":[{"id":"10.13039\/100009821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronary microvascular dysfunction (CMD) is associated with heart failure with preserved ejection fraction (HFpEF); however, pathophysiology is not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that CMD in women with suspected ischemia with no obstructive coronary artery disease (INOCA) is associated with cardiomyocyte dysfunction reflected by plasma levels of a cardiomyocyte calcium handling protein, cardiac bridge integrator 1 (cBIN1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with suspected INOCA undergoing coronary function testing were included. Coronary flow reserve, vasodilation to nitroglycerin, change in coronary blood flow (\u0394CBF), and vasodilation to acetylcholine (\u0394Ach) were evaluated. cBIN1 score (CS) levels in these women (n\u00a0=\u00a039) were compared to women with HFpEF (n\u00a0=\u00a020), heart failure with reduced ejection fraction (HFrEF) (n\u00a0=\u00a036), and reference controls (RC) (n\u00a0=\u00a050). Higher CS indicates cardiomyocyte tubule dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>INOCA, HFpEF, and HFrEF women were older than RC (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Higher CS was associated with vasoconstriction to acetylcholine (r\u00a0=\u00a0\u22120.43, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.011) with a trend towards lower \u0394CBF (r\u00a0=\u00a00.30, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.086). Higher CS was specific for \u0394Ach and \u0394CBF but had limited sensitivity. INOCA women had higher CS than RC, but lower CS than HFpEF\/HFrEF groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CS, a plasma biomarker indicating poor cardiomyocyte health, was higher in women with suspected INOCA as compared to RC, but lower than in women with HFpEF. Elevated CS in suspected INOCA patients represents an intermediate group between health and disease, supporting the hypothesis that CMD may progress to HFpEF. Larger prospective cohort studies are needed to confirm the pathophysiological relationship between cBIN1, CMD, and HFpEF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23726","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T09:27:22Z","timestamp":1631784442000},"page":"1586-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of coronary microvascular dysfunction and cardiac bridge integrator 1, a cardiomyocyte dysfunction biomarker"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1355-2632","authenticated-orcid":false,"given":"Christine","family":"Pacheco","sequence":"first","affiliation":[{"name":"H\u00f4pital Pierre\u2010Boucher Cardiology Service, Department of Medicine, Universit\u00e9 de Montr\u00e9al  Longueuil Quebec Canada"},{"name":"Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), Cardiology Service, Department of Medicine, Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Wei","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Smidt Heart Institute, Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrisandra","family":"Shufelt","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Smidt Heart Institute, Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"C. Hitzeman","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galen","family":"Cook\u2010Wiens","sequence":"additional","affiliation":[{"name":"Barbra Streisand Women's Heart Center Smidt Heart Institute, Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-681X","authenticated-orcid":false,"given":"Carl J.","family":"Pepine","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Handberg","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. David","family":"Anderson","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Petersen","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TingTing","family":"Hong","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"M. Shaw","sequence":"additional","affiliation":[{"name":"Nora Eccles Harrison Cardiovascular Research and Training Institute University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-5155","authenticated-orcid":false,"given":"C. 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