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We aimed to describe the body mass index (BMI) distribution in a nationwide cohort of patients admitted for an out of hospital SCD (OHSCD), and the relationship between BMI and in\u2010hospital mortality. We drew data from the U.S. National Inpatient Sample (NIS), to identify cases of OHSCD. Patients were divided into six groups based on their BMI (underweight, normal weight, overweight, obese I, obese II, extremely obese). Socio\u2010demographic and clinical data were collected, mortality and length of stay were analyzed. Multivariate analysis was performed to identify predictors of mortality. Among a weighted total of 2330 hospitalizations for OHSCD in patients with documented BMI, the mean age was 62.3\u00a0\u00b1\u200929\u2009years, 52.4% were male and 62% were white. The overall rate of in\u2010hospital mortality was 69.3%. A U\u2010shaped relationship between the BMI and mortality was documented, as patients with 25\u2009&lt;\u2009BMI\u2009&lt;\u200940 exhibited significantly lower mortality (60.7%) compared to the other BMI groups (75.2%), <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001. BMI of 25\u2009kg\/m<jats:sup>2<\/jats:sup> and below or 40\u2009kg\/m<jats:sup>2<\/jats:sup> and above, were independent predictors of in\u2010hospital mortality in a multivariate analysis along with prior history of congestive heart failure and Deyo Comorbidity Index of \u22652. A U\u2010shaped relationship between the BMI and in\u2010hospital mortality was documented in patients hospitalized for an out of hospital sudden cardiac death in the United States in the recent years.<\/jats:p>","DOI":"10.1002\/clc.23730","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T07:26:03Z","timestamp":1637133963000},"page":"1673-1682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The relationship between the body mass index and in\u2010hospital mortality in patients admitted for sudden cardiac death in the United States"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0335-9225","authenticated-orcid":false,"given":"Guy","family":"Rozen","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Hillel Yaffe Medical Center  Hadera Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine Technion  Haifa Israel"},{"name":"Cardiac Arrhythmia Service Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-9174","authenticated-orcid":false,"given":"Gabby","family":"Elbaz\u2010Greener","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hadassah Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Marai","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Baruch Padeh Medical Center  Poriya Israel"},{"name":"The Azrieli Faculty of Medicine Bar\u2010Ilan University  Zafed Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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