{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:08:50Z","timestamp":1788480530120,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left ventricular thrombus (LVT) is a rare but dreaded complication during the acute phase of acute coronary syndrome (ACS). However, profound data on long\u2010term outcome and associated antithrombotic treatment strategies of this highly vulnerable patient population are scarce in current literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients presenting with ACS were screened for presence of LVT and subsequently included within a prospective clinical registry. All\u2010cause mortality and the composite of major adverse cardiac events (MACE) and thromboembolic events were defined as primary and secondary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within 43 patients presenting with LVT, thrombus resolution during patient follow\u2010up was observed in 27 individuals (62.8%). Patients that reached a resolution of LVT experienced lower incidence rates of death (\u221223.9%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022), MACE (\u221237.8%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005), and thromboembolic events (\u221235.2%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008). Even after adjustment for clinical variables, thrombus resolution showed an independent inverse association with all\u2010cause death with a hazard ratio (HR) of 0.14 (95% CI: 0.03\u20130.75; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.021) and as well with MACE with a HR of 0.22 (95% CI: 0.07\u20130.68; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008) and thromboembolic events with a HR of 0.22 (95% CI: 0.06\u20130.75; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.015). Triple antithrombotic therapy (TAT) with ticagrelor\/prasugrel showed a strong and independent association with thrombus resolution with an adjusted HR of 3.25 (95% CI: 1.22\u20138.68; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.019) compared to other strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presented data indicate a poor outcome of ACS patients experiencing LVT. In terms of a personalized risk stratification, thrombus resolution has a strong protective impact on both all\u2010cause death and MACE with the potential to tailor treatment decisions\u2014including an intensified antithrombotic treatment approach\u2014in this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23741","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T01:10:42Z","timestamp":1634778642000},"page":"1692-1699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The prognostic impact of left ventricular thrombus resolution after acute coronary syndrome and risk modulation via <scp>antithrombotic<\/scp> treatment strategies"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0185-7511","authenticated-orcid":false,"given":"Felix","family":"Hofer","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niema","family":"Kazem","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Horvat","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max\u2010Paul","family":"Winter","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Koller","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hengstenberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sulzgruber","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Niessner","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine 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