{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:29:09Z","timestamp":1784734149459,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There are no consistently confirmed predictors of atrial fibrillation (AF) recurrence after catheter ablation. Therefore, we aimed to study whether left atrial appendage volume (LAAV) and function influence the long\u2010term recurrence of AF after catheter ablation, depending on AF type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AF patients who underwent point\u2010by\u2010point radiofrequency catheter ablation after cardiac computed tomography (CT) were included in this analysis. LAAV and LAA orifice area were measured by CT. Uni\u2010 and multivariable Cox proportional hazard regression models were performed to determine the predictors of AF recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 561 AF patients (61.9\u2009\u00b1\u200910.2\u2009years, 34.9% females) were included in the study. Recurrence of AF was detected in 40.8% of the cases (34.6% in patients with paroxysmal and 53.5% in those with persistent AF) with a median recurrence\u2010free time of 22.7 (9.3\u201343.1) months. Patients with persistent AF had significantly higher body surface area\u2010indexed LAV, LAAV, and LAA orifice area and lower LAA flow velocity, than those with paroxysmal AF. After adjustment left ventricular ejection fraction (LVEF) &lt;50% (HR\u00a0=\u00a02.17; 95% CI\u00a0=\u00a01.38\u20133.43; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and LAAV (HR\u00a0=\u00a01.06; 95% CI\u00a0=\u00a01.01\u20131.12; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.029) were independently associated with AF recurrence in persistent AF, while no independent predictors could be identified in paroxysmal AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study demonstrates that beyond left ventricular systolic dysfunction, LAA enlargement is associated with higher rate of AF recurrence after catheter ablation in persistent AF, but not in patients with paroxysmal AF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23748","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T07:19:26Z","timestamp":1637392766000},"page":"273-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Left atrial appendage size is a marker of atrial fibrillation recurrence after radiofrequency catheter ablation in patients with persistent atrial fibrillation"],"prefix":"10.1002","volume":"45","author":[{"given":"Judit","family":"Simon","sequence":"first","affiliation":[{"name":"MTA\u2010SE Cardiovascular Imaging Research Group, Heart and Vascular Center Semmelweis University  Budapest Hungary"},{"name":"Medical Imaging Centre Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"El Mahdiui","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff M.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Sz\u00e1raz","sequence":"additional","affiliation":[{"name":"MTA\u2010SE Cardiovascular Imaging Research Group, Heart and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"van Rosendael","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilvia","family":"Herczeg","sequence":"additional","affiliation":[{"name":"Heat and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-8478","authenticated-orcid":false,"given":"Emese","family":"Zsarn\u00f3czay","sequence":"additional","affiliation":[{"name":"MTA\u2010SE Cardiovascular Imaging Research Group, Heart and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3 Ilona","family":"Nagy","sequence":"additional","affiliation":[{"name":"Heat and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton","family":"Kolossv\u00e1ry","sequence":"additional","affiliation":[{"name":"MTA\u2010SE Cardiovascular Imaging Research Group, Heart and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Szilveszter","sequence":"additional","affiliation":[{"name":"MTA\u2010SE Cardiovascular Imaging Research Group, Heart and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor","family":"Szegedi","sequence":"additional","affiliation":[{"name":"Heat and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia Vivien","family":"Nagy","sequence":"additional","affiliation":[{"name":"Heat and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Tahin","sequence":"additional","affiliation":[{"name":"Heat and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Gell\u00e9r","sequence":"additional","affiliation":[{"name":"Heat and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J.","family":"van der Geest","sequence":"additional","affiliation":[{"name":"Division of Image Processing Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J.","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Heart Center Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-736X","authenticated-orcid":false,"given":"P\u00e1l","family":"Maurovich\u2010Horvat","sequence":"additional","affiliation":[{"name":"MTA\u2010SE Cardiovascular Imaging Research Group, Heart and Vascular Center Semmelweis University  Budapest Hungary"},{"name":"Medical Imaging Centre Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[{"name":"MTA\u2010SE Cardiovascular Imaging Research Group, Heart and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2017.08.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735\u20101097(00)00886\u2010x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072767.89944.6E"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.22.8.983"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050955"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000157153.30978.67"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.21.2634"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy326"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.06.014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.10.016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.12.021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108175.2009.01123.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108159.2006.00356.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.12.019"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.060"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540\u20108167.2004.03538.x"},{"issue":"2","key":"e_1_2_10_18_1","first-page":"53","article-title":"Predictors of successful catheter ablation for atrial fibrillation using the pulmonary vein isolation technique","volume":"44","author":"Yasuda T","year":"2004","journal-title":"J Cardiol"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm027"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.928903"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010017\u20104866\u20100"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw295"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.031"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.04.005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612820666140825144226"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.962100"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.051"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108167.2008.01101.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001182"},{"issue":"19","key":"e_1_2_10_30_1","first-page":"3425","article-title":"Efficacy of catheter ablation of atrial fibrillation beyond HATCH score","volume":"125","author":"Tang RB","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392\u2010015\u20100856\u2010x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.770"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253\u20103758.2017.11.006"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840\u2010017\u20100256\u20104"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109149(97)00903\u2010x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.001752"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1054\u20108807(00)00030\u20102"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109149(96)00419\u20105"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23748","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T07:03:32Z","timestamp":1693119812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,19]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/clc.23748"],"URL":"https:\/\/doi.org\/10.1002\/clc.23748","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,19]]},"assertion":[{"value":"2021-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}