{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T02:21:33Z","timestamp":1764210093750,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of antiarrhythmic drugs (AADs) in patients with chronic kidney disease (CKD) is complex because impaired renal clearance can cause increased drug levels, and risk of intolerance or adverse events. Due to the propensity for CKD to occur alongside atrial fibrillation\/atrial flutter (AF\/AFL), it is essential that AAD safety and efficacy are assessed for patients with CKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Dronedarone, an approved AAD, may present a suitable therapeutic option for patients with AF\/AFL and concomitant CKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EURIDIS\u2010ADONIS (EURIDIS, NCT00259428; ADONIS, NCT00259376) were identically designed, multicenter, double\u2010blind, parallel\u2010group trials investigating AF\/AFL control with dronedarone 400\u2009mg twice daily versus placebo (randomized 2:1). In this post hoc analysis, the primary endpoint was time to first AF\/AFL. Patients were stratified according to renal function using the CKD\u2010Epidemiology Collaboration equation and divided into estimated glomerular filtration rate (eGFR) subgroups of 30\u201344, 45\u201359, 60\u201389, and \u226590\u2009ml\/min. Time\u2010to\u2010events between treatment groups were compared using log\u2010rank testing and Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, most (86%) patients demonstrated a mild or mild\u2010to\u2010moderate eGFR decrease. Median time to first AF\/AFL recurrence was significantly longer with dronedarone versus placebo for all eGFR subgroups except the 30 to 44 ml\/min group, where the trend was similar but statistical power may have been limited by the small population. eGFR stratification had no significant effect on serious adverse events, deaths, or treatment discontinuations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis suggests that dronedarone could be an effective therapeutic option for AF with an acceptable safety profile in patients with impaired renal function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23765","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T11:43:27Z","timestamp":1641987807000},"page":"101-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of dronedarone versus placebo in patients with atrial fibrillation stratified according to renal function: Post hoc analyses of the EURIDIS\u2010ADONIS trials"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9852-2867","authenticated-orcid":false,"given":"Munveer","family":"Thind","sequence":"first","affiliation":[{"name":"Division of Cardiology Lankenau Heart Institute Wynnewood Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Rochester Medical Center Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-8793","authenticated-orcid":false,"given":"Dan","family":"Atar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Ulleval Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-5337","authenticated-orcid":false,"given":"Harry J. 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