{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:04:02Z","timestamp":1790751842063,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070239"],"award-info":[{"award-number":["82070239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (AF) is common arrhythmia in valvular heart disease (VHD) and is associated with adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>To evaluate the left atrial (LA) function in patients with AF\u2010VHD by cardiovascular magnetic resonance imaging feature tracking (CMR\u2010FT) using LA strain (<jats:italic>\u03b5<\/jats:italic><jats:sub>s<\/jats:sub>\/<jats:italic>\u03b5<\/jats:italic><jats:sub>e<\/jats:sub>\/<jats:italic>\u03b5<\/jats:italic><jats:sub>a<\/jats:sub>) and their corresponding strain rate (SRs\/SRe\/SRa).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cross\u2010sectional inter\u2010reader and intra\u2010reader reproducibility conducted from July 1, 2020, to January 31, 2021. A total of 39 patients with AF\u2010VHD (rheumatic heart valvular disease [RHVD] [<jats:italic>n<\/jats:italic>\u2009=\u200922], degenerative heart valvular disease [DHVD] [<jats:italic>n<\/jats:italic>\u2009=\u200917]) underwent MRI scans performed with drug\u2010controlled heart rate before correcting the rhythm and valves through maze procedure. Fifteen participants with normal cardiac MRI were included as healthy control. <jats:italic>\u03b5<\/jats:italic><jats:sub>s<\/jats:sub>\/SRs, <jats:italic>\u03b5<\/jats:italic><jats:sub>e<\/jats:sub>\/SRe, and <jats:italic>\u03b5<\/jats:italic><jats:sub>a<\/jats:sub>\/SRa, corresponding to LA reservoir, conduit, and booster\u2010pump function, were assessed using Feature Tracking software (CVI42 v5.12.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy controls, LA global strain parameters (<jats:italic>\u03b5<\/jats:italic><jats:sub>s<\/jats:sub>\/<jats:italic>\u03b5<\/jats:italic><jats:sub>e<\/jats:sub>\/<jats:italic>\u03b5<\/jats:italic><jats:sub>a<\/jats:sub>\/SRs\/SRe\/SRa) were significantly decreased (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while LA size and volume were increased in AF\u2010VHD group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In the subgroup, RHVD group showed lower LA total ejection fraction (LATEF) and strain data than DHVD group (12.6%\u2009\u00b1\u20093.3% vs. 19.4\u2009\u00b1\u20098.6, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Decreased LATEF was significantly related to altered LA strain and strain rate, especially in <jats:italic>\u03b5<\/jats:italic><jats:sub>s<\/jats:sub>, <jats:italic>\u03b5<\/jats:italic><jats:sub>e<\/jats:sub>, and SRs (Pearson\/Spearman <jats:italic>r\/\u03c1<\/jats:italic>\u2009=\u20090.856\/0.837\/0.562, respectively; all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Interstudy and intrastudy reproducibility were consistent for LA volumetry and strain parameters (intraclass correlation coefficient: 0.88\u20130.99).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CMR\u2010FT can be used to assess the LA strain parameters, and identify LA dysfunction and deformation noninvasively, which could be a helpful functional imaging biomarker in the clinical treatment of AF\u2010VHD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23811","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T09:10:05Z","timestamp":1647335405000},"page":"527-535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessing left atrial function in patients with atrial fibrillation and valvular heart disease using cardiovascular magnetic resonance 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