{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:41:56Z","timestamp":1778247716498,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adenosine has been recommended as a first\u2010line treatment for stable supraventricular tachycardia (SVT). Standard guidelines recommend 6\u2010mg of adenosine administered intravenously (IV) with an immediate 20\u2010ml IV bolus of normal saline solution (NSS; double syringe technique [DST]). However, a newly proposed single\u2010syringe technique (SST), in which adenosine is diluted with an up to 20\u2009ml IV bolus of NSS, was found to be beneficial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that the SST was noninferior to the DST for terminating stable SVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pilot multicenter, single\u2010blind, randomized controlled study was conducted at nine hospitals in north and northeast Thailand. Thirty patients who were diagnosed with stable SVT were randomized into two groups of 15, with one receiving adenosine via the DST and the other via the SST. We examined SVT termination, the average successful dose, and the complication rate of each group. Analyses were based on the intention\u2010to\u2010treat principle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The termination rate was 93.3% in the DST and 100% in the SST group (<jats:italic>p<\/jats:italic>\u2009=\u20091.000), and the success rate of the first 6\u2010mg dose of adenosine was 73.3% and 80%, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20091.000). The total administered dose was 8.6\u2009\u00b1\u20095.1\u2009mg in the DST group and 7.6\u2009\u00b1\u20094.5\u2009mg in the SST group (<jats:italic>p<\/jats:italic>\u2009=\u2009.608). No complications were found in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SST was non\u2010inferior to the DST for termination of SVT. However, a further definitive study with a larger sample size is required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23820","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T07:58:21Z","timestamp":1648367901000},"page":"583-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison between the double\u2010syringe and the single\u2010syringe techniques of adenosine administration for terminating supraventricular tachycardia: A pilot, randomized controlled trial"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3519-3415","authenticated-orcid":false,"given":"Praew","family":"Kotruchin","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine Khon Kaen University Muang Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itchaya\u2010on","family":"Chaiyakhan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine Khon Kaen University Muang Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phimonphorn","family":"Kamonsri","sequence":"additional","affiliation":[{"name":"Emergency Medicine Unit Srisaket Hospital Muang Srisaket Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wittawin","family":"Chantapoh","sequence":"additional","affiliation":[{"name":"Kukan Hospital  Srisaket Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nattapat","family":"Serewiwattana","sequence":"additional","affiliation":[{"name":"Emergency Medicine Unit Queen Sirikit Heart Center of the Northeast Khon Kaen 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