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Anti\u2010COVID\u201019 vaccinations have had exceptional success in subduing the incidence, prevalence, and disease severity of COVID\u201019, but rare cases of myocarditis have been reported after COVID\u201019 vaccinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Myocarditis occurring after COVID\u201019 mRNA vaccinations have distinguishable clinical characteristics. They usually have a favorable prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic literature search on PUBMED and MEDLINE database from inception to December 5, 2021. Studies were analyzed based on predetermined eligibility criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 57 studies containing 275 cases of COVID\u201019 vaccine\u2010associated myocarditis were catalogued. Mean age was 26.7 years\u00a0and male to female ratio was 14:1. For 86.9% of patients, myocarditis occurred after the second dose. Average time to onset and length of hospitalization were 3.7\u00a0and 3.9 days, respectively. Prognosis was largely benign, but there was a 1.1% reported mortality. Chest pain (95.2%), elevation of troponin (100%), and ST elevation on electrocardiography\u00a0(68.5%) were common. Nonsteroidal anti\u2010inflammatory drugs\u00a0(81.4%) were the most used medication, followed by colchicine (33.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with COVID\u201019 vaccine\u2010associated myocarditis are usually younger males presenting with chest pain 3\u20134 days after receiving their second dose of COVID vaccine. Diagnosis is made by exclusion of all other etiologies. Given significant population benefit from COVID\u201019 vaccination, physicians should continue to encourage vaccination while remaining vigilant of the very rare occurrence of myocarditis following COVID\u201019 vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23828","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T09:39:57Z","timestamp":1654162797000},"page":"691-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Myocarditis after COVID\u201019 mRNA vaccination: A systematic review of case reports and case series"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1486-7452","authenticated-orcid":false,"given":"Dae Yong","family":"Park","sequence":"first","affiliation":[{"name":"Department of Medicine John H. 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