{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:05:24Z","timestamp":1772107524786,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL159945"],"award-info":[{"award-number":["R01 HL159945"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18TPA34170579"],"award-info":[{"award-number":["18TPA34170579"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gout is a common comorbidity in heart failure (HF) patients and is frequently associated with acute exacerbations during treatment for decompensated HF. Although colchicine is often used to manage acute gout in HF patients, its impact on clinical outcomes when used during acute decompensated HF is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single center, retrospective study of hospitalized patients treated for an acute HF exacerbation with and without acute gout flare between March 2011 and December 2020. We assessed clinical outcomes in patients treated with colchicine for a gout flare compared to those who did not experience a gout flare or receive colchicine. The primary outcome was in\u2010hospital all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1047 patient encounters for acute HF during the study period, there were 237 encounters (22.7%) where the patient also received colchicine for acute gout during admission. In\u2010hospital all\u2010cause mortality was significantly reduced in the colchicine group compared with the control group (2.1% vs. 6.5%, <jats:italic>p<\/jats:italic>\u2009=\u2009.009). The colchicine group had increased length of stay (9.93\u00a0vs. 7.96 days, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) but no significant difference in 30\u2010day readmissions (21.5% vs. 19.5%, <jats:italic>p<\/jats:italic>\u2009=\u2009.495). In a Cox proportional hazards model adjusted for age, inpatient colchicine use was associated with improved survival to discharge (hazards ratio [HR] 0.163, 95% confidence interval [CI] 0.051\u22120.525, <jats:italic>p<\/jats:italic>\u2009=\u2009.002) and a reduced rate of in\u2010hospital CV mortality (HR 0.184, 95% CI 0.044\u22120.770, <jats:italic>p<\/jats:italic>\u2009=\u2009.021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with a HF exacerbation, treatment with colchicine for a gout flare was associated with significantly lower in\u2010hospital mortality compared with those not treated for acute gout.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23830","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T12:15:49Z","timestamp":1651148149000},"page":"733-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of colchicine use for acute gout with clinical outcomes in acute decompensated heart failure"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7324-0588","authenticated-orcid":false,"given":"Mary E.","family":"Roth","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Virginia Health Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa E.","family":"Chinn","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Virginia Health Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven P.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Virginia Health Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth C.","family":"Bilchick","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2014Cardiovascular Medicine University of Virginia Health Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sula","family":"Mazimba","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2014Cardiovascular Medicine University of Virginia Health Charlottesville Virginia 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of acute gout flare in patients initiated on intravenous bumetanide for acute heart failure exacerbation","volume":"12","author":"Jeong 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