{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:17:20Z","timestamp":1785763040742,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20202ACBL206002"],"award-info":[{"award-number":["20202ACBL206002"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lipoprotein(a) [Lp(a)] is associated with coronary atherosclerotic heart disease, aortic stenosis, stroke, and heart failure. We aimed to determine the relationship between Lp(a) and aortic dissection (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred patients with AD were included in our case group. The control group consisted of 200 non\u2010AD people who were age\u2010 (\u00b15 years) and gender\u2010matched to the case group. Data were collected retrospectively, including hypertension, smoking, coronary artery disease, diabetes mellitus, Lp(a), total cholesterol, triglyceride, low\u2010density lipoprotein cholesterol, and high\u2010density lipoprotein cholesterol. The association between Lp(a) and AD was studied using univariate and multivariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with AD had greater median Lp(a) concentrations than non\u2010AD people (152.50 vs. 81.75\u2009mg\/L). Lp(a) was associated with AD in a multivariate logistic regression analysis (odds ratio, 8.03; 95% confidence interval, 2.85\u201322.62),\u00a0comparing those with Lp(a) quartile 4 with those with Lp(a) quartile 1. Stratified analysis showed that this relationship was observed in both men and women, as well as in older and younger individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High levels of Lp(a) are strongly associated with AD, independent of other cardiovascular risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23834","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T14:04:40Z","timestamp":1659621880000},"page":"908-912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of lipoprotein(a) with aortic dissection\u00a0"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8053-9871","authenticated-orcid":false,"given":"Yiheng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The First Affiliated Hospital of Nanchang University Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine The First Affiliated Hospital of Nanchang University Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Affiliated Renhe Hospital of China Three Gorges University Yichang Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9239-3996","authenticated-orcid":false,"given":"Zhenzhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The First Affiliated Hospital of Nanchang University Nanchang Jiangxi 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