{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:57:18Z","timestamp":1780671438264,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170387"],"award-info":[{"award-number":["82170387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives to Background<\/jats:title><jats:p>To compare electromechanical ventricular synchrony when pacing from different sites, including right ventricular apex pacing (RVAP), right ventricular septum pacing (RVSP), His bundle pacing (HBP), left bundle branch pacing (LBBP), and RVSP during unipolar pacing from the ring electrode of LBBP lead (RVSP<jats:sub>ring<\/jats:sub>) in each patient and evaluate the correlations between electrophysiological characteristics and ventricular synchrony.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients with complete atrioventricular block\u00a0indicated for dual\u2010chamber pacemaker implantation were included in the study. Unipolar pacing at different sites, including RVAP,\u00a0RVSP,\u00a0HBP,\u00a0LBBP, and RVSP<jats:sub>ring<\/jats:sub>, was successively performed in each patient. The pacing characteristics and echocardiogram parameters were collected and compared among intrinsic rhythm and pacing at different sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Similar to HBP (114.84\u2009\u00b1\u200918.67\u2009ms), narrower paced QRSd was found in LBBP (116.15\u2009\u00b1\u200911.60\u2009ms) as compared to RVSP<jats:sub>ring<\/jats:sub> (135.11\u2009\u00b1\u200913.68\u2009ms), RVSP (141.65\u2009\u00b1\u200914.26\u2009ms), and RVAP (160.15\u2009\u00b1\u200919.35\u2009ms) (<jats:italic>p\u2009<\/jats:italic>&lt;\u2009.001). LBBP showed comparable pacing parameters to RVAP or RVSP and was significantly better than HBP, with maintained cardiac function. TS\u201012\u2010SD was significantly improved in LBBP (41.80\u2009\u00b1\u200920.97\u2009ms) than RVAP (69.70\u2009\u00b1\u200932.42\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u2009.003) and RVSP (63.30.56\u2009\u00b1\u200932.53\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u2009.018) but similar to HBP (51.50\u2009\u00b1\u200925.67\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u2009.283) or RVSP<jats:sub>ring<\/jats:sub> (57.80\u2009\u00b1\u200925.65\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u2009.198). Among these pacing strategies, negative values of interventricular mechanical delay (IVMD) were only identified in LBBP (\u221219.25\u2009\u00b1\u200918.43\u2009ms), significantly different from RVAP (35.00\u2009\u00b1\u200930.72\u2009ms), RVSP (22.85\u2009\u00b1\u200922.05\u2009ms), HBP (5.20\u2009\u00b1\u200918.64\u2009ms), and RVSP<jats:sub>ring<\/jats:sub> (16.00\u2009\u00b1\u200926.76\u2009ms (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Using Pearson's analysis, Sti\u2010LVAT was positively correlated with QRS duration, IVMD, TS\u201012\u2010SD, LVEDV, and LVESV, while a negative relationship could be observed for left ventricular ejection fraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>His\u2010Purkinje conduction system pacing (HPCSP) achieved better electrical and mechanical synchrony than conventional RV pacing. For interventricular synchrony, only LBBP initiated earlier LV activation than RV, in accordance with the right bundle branch block\u00a0(RBBB) pattern of paced QRS during LBBP. Sti\u2010LVAT might be a good parameter correlating with\u00a0LV systolic function and mechanical synchrony.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23837","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T08:43:09Z","timestamp":1651567389000},"page":"723-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of electrophysiological characteristics and ventricular synchrony: An intrapatient\u2010controlled study during His\u2010Purkinje conduction system pacing\u00a0versus right ventricular pacing"],"prefix":"10.1002","volume":"45","author":[{"given":"Xueying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Huashan Worldwide Medical Center, Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Echocardiology, Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinchun","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Echocardiology, Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengmei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Clinical Research Center for Interventional Medicine, Shanghai Clinical Research Center for Interventional Medicine, Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National 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