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We review the conventional approach to sequencing these therapies in HFrEF and proposed new rapid sequencing strategies. We review a recent modelling study suggesting the optimal sequence of treatment includes a sodium\u2010glucose cotransporter 2 inhibition and an MRA as the first two therapies. Finally, we review the important opportunity offered by hospitalization for worsening heart failure to initiate and optimize foundational therapies in patients at high risk of early adverse outcomes.<\/jats:p>","DOI":"10.1002\/clc.23847","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T11:52:34Z","timestamp":1657021954000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Insights into foundational therapies for heart failure with reduced ejection fraction"],"prefix":"10.1002","volume":"45","author":[{"given":"John J. 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