{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T08:28:58Z","timestamp":1769329738132,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although predictors of reverse left ventricular (LV) remodeling postmitral valve repair are critical for guiding perioperative decision\u2010making, there remains a paucity of randomized, prospective data to support the criteria that potential predictor variables must meet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The CAMRA CardioLink\u20102 randomized trial allocated 104 patients to either leaflet resection or preservation strategies for mitral repair. The correlation of indexed left ventricular end\u2010systolic volume (LVESVI), indexed left ventricular end\u2010diastolic volume (LVEDVI), and left ventricular ejection fraction (LVEF) were tested with univariate analysis and subsequently with multivariate analysis to determine independent predictors of reverse remodeling at discharge and at 12 months postoperatively. At discharge, both LVESVI and LVEDVI were independently associated with their preoperative values (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 for both) and LVEF by preoperative LVESVI (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Mitral ring size was favorably associated with the change in LVESVI (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) and LVEF (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) from predischarge to 12 months, while the mean mitral valve gradient after repair was adversely associated with the change in LVESVI (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) and LVEDVI (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). No significant associations were found between reverse remodeling and coaptation height nor mitral repair technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Beyond confirming the lack of impact of mitral repair technique on reverse remodeling, this investigation suggests that recommending surgery before significant LV dilatation or dysfunction, as well as higher postoperative mitral valve hemodynamic performance, may enhance remodeling capacity following mitral repair.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23879","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T07:39:42Z","timestamp":1656056382000},"page":"921-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Stage\u2010based approach to predict left ventricular reverse remodeling after mitral repair"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0017-8744","authenticated-orcid":false,"given":"Makoto","family":"Hibino","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery Li Ka Shing Knowledge Institute of St. Michael's Hospital Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitish K.","family":"Dhingra","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Li Ka Shing Knowledge Institute of St. Michael's Hospital Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery University of Ottawa Heart Institute Ottawa Ontario Canada"},{"name":"School of Epidemiology, Public Health and Preventive Medicine University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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