{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:38:20Z","timestamp":1781059100386,"version":"3.54.1"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the clinical signs and mechanisms (viral and autoimmune) of myoendocarditis in the long\u2010term period after COronaVIrus Disease 2019\u00a0(COVID\u201019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen patients (nine male, 50.1\u2009\u00b1\u200910.2\u2009y.o.) with biopsy proven post\u2010COVID myocarditis were observed. The diagnosis of COVID\u201019 was confirmed by IgG seroconversion. The average time of admission after COVID\u201019 was 5.5 [2; 10] months. An endomyocardial biopsy (EMB) of the right ventricle was obtained. The biopsy analysis included polymerase chain reaction diagnosis of viral infection, morphological, immunohistochemical (IHC) examination with antibodies to CD3, CD45, CD68, CD20, SARS\u2010Cov\u20102 spike, and nucleocapsid antigens. Coronary atherosclerosis was ruled out in all patients over 40\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The new cardiac symptoms (congestive heart failure 3\u20134 New York Heart Association class with severe right ventricular involvement, various rhythm, and conduction disturbances) appeared 1\u20135\u2009months following COVID\u201019. Magnetic resonance imaging showed disseminated or focal subepicardial and intramyocardial late gadolinium enhancement, hyperemia, edema, and increased myocardial native T1 relaxation time. Antiheart antibodies levels were increased 3\u20134 times in 92.9% of patients. The mean left ventricular (LV) ejection fraction\u00a0(EF) was 28% (24.5; 37.8). Active lymphocytic myocarditis was diagnosed in 12 patients, eosinophilic myocarditis in two patients. SARS\u2010Cov\u20102 RNA was detected in 12 cases (85.7%), in association with parvovirus B19 DNA\u2014in one. Three patients had also endocarditis (infective and nonbacterial, with parietal thrombosis). As a result of steroid and chronic heart failure therapy, the EF increased to 47% (37.5; 52.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>COVID\u201019 can lead to long\u2010term severe post\u2010COVID myoendocarditis, that is characterized by prolonged persistence of coronavirus in cardiomyocytes, endothelium, and macrophages (up to 18\u2009months) in combination with high immune activity. Corticosteroids and anticoagulants should be considered as a treatment option of post\u2010COVID myoendocarditis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23886","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T06:44:55Z","timestamp":1658299495000},"page":"952-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Chronic biopsy proven post\u2010COVID myoendocarditis with SARS\u2010Cov\u20102 persistence and high level of antiheart antibodies"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-793X","authenticated-orcid":false,"given":"Olga","family":"Blagova","sequence":"first","affiliation":[{"name":"Department of Faculty Therapy No.1 N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Lutokhina","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy No.1 N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Kogan","sequence":"additional","affiliation":[{"name":"Department of Pathology N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kukleva","sequence":"additional","affiliation":[{"name":"Department of Pathology N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara","family":"Ainetdinova","sequence":"additional","affiliation":[{"name":"Department of Cardiology N2 of V.N. Vinogradov Faculty Therapeutic Clinic I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Novosadov","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy No.1 N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-3634","authenticated-orcid":false,"given":"Ruslan","family":"Rud'","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy No.1 N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Savina","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy No.1 N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zaitsev","sequence":"additional","affiliation":[{"name":"Department of Endovascular Methods of Diagnostics and Treatment I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Fomin","sequence":"additional","affiliation":[{"name":"Department of Faculty Therapy No.1 N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1828"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12805"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2020.7.n1209"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.10.012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa286"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-020-02500-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13047"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048930"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23886","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:11:40Z","timestamp":1692756700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,19]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/clc.23886"],"URL":"https:\/\/doi.org\/10.1002\/clc.23886","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,19]]},"assertion":[{"value":"2022-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}