{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T05:30:36Z","timestamp":1751261436989,"version":"3.37.3"},"reference-count":54,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The number\u00a0of MitraClip\u00ae implantations increased significantly in recent years. Data regarding the impact of weight class on survival are sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that weight class influences survival of patients treated with MitraClip\u00ae implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated in\u2010hospital, 1\u2010year, 3\u2010year, and long\u2010term survival of patients successfully treated with isolated MitraClip\u00ae implantation for mitral valve regurgitation (MR)\u00a0(June 2010\u2013March 2018). Patients were categorized by weight classes, and the impact of weight classes on survival was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 617 patients (aged 79.2 years; 47.3% females) treated with MitraClip\u00ae implantation (June 2010\u2013March 2018), 12 patients were underweight (2.2%), 220 normal weight (40.1%), 237 overweight (43.2%), and 64 obesity class I (11.7%), 12 class II (2.2%), and 4 class III (0.7%). Preprocedural Logistic EuroScore (21.1 points [IQR 14.0\u201337.1]; 26.0 [18.5\u201338.5]; 26.0 [18.4\u201339.9]; 24.8 [16.8\u201333.8]; 33.0 [25.9\u201349.2]; 31.6 [13.1\u201347.6]; <jats:italic>p<\/jats:italic>\u2009=\u2009.291) was comparable between groups. Weight class had no impact on in\u2010hospital death (0.0%; 4.1%; 1.5%; 0.0%; 7.7%; 0.0%; <jats:italic>p<\/jats:italic>\u2009=\u2009.189), 1\u2010year survival (75.0%; 72.0%; 76.9%; 75.0%; 75.0%; 33.3%; <jats:italic>p<\/jats:italic>\u2009=\u2009.542), and 3\u2010year survival (40.0%; 36.8%; 38.2%; 48.6%; 20.0%; 33.3%; <jats:italic>p<\/jats:italic>\u2009=\u2009.661). Compared to normal weight, underweight (hazard ratio [HR]: 1.35 [95% confidence interval [CI]: 0.65\u20132.79], <jats:italic>p<\/jats:italic>\u2009=\u2009.419), obesity\u2010class I (HR: 0.93 [95%\u00a0CI: 0.65\u20131.34], <jats:italic>p<\/jats:italic>\u2009=\u2009.705), class II (HR: 0.39 [95%\u00a0CI: 0.12\u20131.24], <jats:italic>p<\/jats:italic>\u2009=\u2009.112), and class III (HR: 1.28 [95%\u00a0CI: 0.32\u20135.21], <jats:italic>p<\/jats:italic>\u2009=\u2009.726) did not affect long\u2010term survival. In contrast, overweight was associated with better survival (HR: 1.32 [95%\u00a0CI: 1.04\u20131.68], <jats:italic>p<\/jats:italic>\u2009=\u2009.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overweight affected the long\u2010term survival of patients undergoing MitraClip\u00ae implantation beneficially compared to normal weight.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23897","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T19:03:26Z","timestamp":1662577406000},"page":"1236-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Survival benefit of overweight patients undergoing MitraClip\u00ae procedure in comparison to normal\u2010weight 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