{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:36:02Z","timestamp":1792197362575,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971041"],"award-info":[{"award-number":["31971041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiovascular medications are vital for the secondary prevention of coronary arterial disease (CAD). However, the effect of cardiovascular medication may depend on the optimal adherence of the patients. This meta\u2010analysis aims to determine the magnitude of adherence to vascular medications that influences the absolute and relative risks (RRs) of mortality in patients with CAD in real\u2010world settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Cochrane Library, PubMed, and EMBASE databases were searched through March 1, 2022. Prospective studies reporting association as RR and 95%\u00a0confidence interval between cardiovascular medication adherence and any cardiovascular events and\/or all\u2010cause mortality in patients with CAD were included. A one\u2010stage robust error meta\u2010regression method was used to summarize the dose\u2010specific relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 18 studies were included. There is a significant inverse linear association between cardiovascular medication adherence and cardiovascular events (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>nonlinearity<\/jats:sub>\n                      \u2009=\u2009.68) or mortality (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>nonlinearity<\/jats:sub>\n                      \u2009=\u2009.82). The exposure\u2010effect analysis showed that an improvement of 20% cardiovascular medication adherence was associated with 8% or 12% lower risk of any cardiovascular events or mortality, respectively. In subgroup analysis, the benefit was observed in adherence of stain (RR: 0.90, for cardiovascular events, RR: 0.85,\u00a0for mortality), angiotensin\u2010converting enzyme inhibitors (ACEI)\/angiotensin II receptor blockers (ARB)(RR: 0.90, for mortality), and antiplatelet agent (RR: 0.89 for mortality) but not in beta\u2010blocker (RR: 0.90,\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.14, for cardiovascular events, RR: 0.97,\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.32 for mortality). Estimated absolute differences per 1 million individuals per year for mortality associated with 20% improvement were 175 cases for statin, 129 cases for antiplatelet,\u00a0and 117 cases for ACEI\/ARB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Evidence from the real word showed poor adherence to vascular medications contributes to a considerable proportion of all cardiovascular disease events\u00a0and mortality in patients with CAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.23898","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T06:00:06Z","timestamp":1663480806000},"page":"1220-1228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Adherence with cardiovascular medications and the outcomes in patients with coronary arterial disease: \u201cReal\u2010world\u201d evidence"],"prefix":"10.1002","volume":"45","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"You","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wan","sequence":"additional","affiliation":[{"name":"Jiangxi Key Laboratory of Molecular Medicine  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-0862","authenticated-orcid":false,"given":"Kui","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"},{"name":"Jiangxi Key Laboratory of Molecular Medicine  Nanchang Jiangxi China"},{"name":"Department of Genetic Medicine The Second Affiliated Hospital of Nanchang University  Nanchang \u00a0Jiangxi 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