{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:01:41Z","timestamp":1768791701721,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["NCATS U24 TR002306"],"award-info":[{"award-number":["NCATS U24 TR002306"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The implications of coronavirus disease 2019\u00a0(COVID\u201019) infection on outcomes after invasive therapeutic strategies among patients presenting with acute myocardial infarction (AMI) are not well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>To assess the outcomes of COVID\u201019 patients presenting with AMI\u00a0undergoing an early invasive treatment strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a cross\u2010sectional, retrospective analysis of the National COVID Cohort Collaborative database including all patients presenting with a recorded diagnosis of AMI (ST\u2010elevation\u00a0myocardial infarction\u00a0(MI) and non\u2010ST elevation MI). COVID\u201019 positive patients with AMI were stratified into one of four groups: (1a) patients who had a coronary angiogram with percutaneous coronary intervention (PCI) within 3 days of their AMI; (1b) PCI within 3 days of AMI with coronary artery bypass graft\u00a0(CABG) within 30 days; (2a) coronary angiogram without PCI and without CABG within 30 days; and (2b) coronary angiogram with CABG within 30 days. The main outcomes were respiratory failure, cardiogenic shock, prolonged length of stay, rehospitalization, and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 10\u2009506 COVID\u201019 positive patients with a diagnosis of AMI. COVID\u201019 positive patients with PCI had 8.2 times higher odds of respiratory failure than COVID\u201019 negative patients (<jats:italic>p<\/jats:italic>\u2009=\u2009.001). The odds of prolonged length of stay were 1.7 times higher in COVID\u201019 patients who underwent PCI (<jats:italic>p<\/jats:italic>\u2009=\u2009.024) and 1.9 times higher in patients who underwent coronary angiogram followed by CABG (<jats:italic>p<\/jats:italic>\u2009=\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data demonstrate that COVID\u201019 positive patients with AMI undergoing early invasive coronary angiography had worse outcomes than COVID\u201019 negative patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23908","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T19:28:00Z","timestamp":1661887680000},"page":"1070-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of COVID\u201019 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-1698","authenticated-orcid":false,"given":"Prerna","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of Virginia Medical Center  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kajal","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Virginia Medical Center  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Loomba","sequence":"additional","affiliation":[{"name":"Integrated Translational Health Research Institute (iTHRIV) University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arti","family":"Patel","sequence":"additional","affiliation":[{"name":"Integrated Translational Health Research Institute (iTHRIV) University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indika","family":"Mallawaarachchi","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Blazek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Virginia Medical Center  Charlottesville Virginia USA"},{"name":"Division of Cardiology University of Connecticut\u2014Hartford Hospital  Mansfield Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Virginia  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijah","family":"Breathett","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Arizona Medical Center  Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Cardiology,\u00a0University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Virginia Medical Center  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Salerno","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Virginia Medical Center  Charlottesville Virginia 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth C.","family":"Bilchick","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Virginia Medical Center  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sula","family":"Mazimba","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Virginia Medical Center  Charlottesville Virginia 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