{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:51:29Z","timestamp":1781203889510,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve replacement (TAVR) is increasingly offered for aortic stenosis (AS) treatment in patients with a history of cancer. The impact of frailty on outcomes in this specific patient population is not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Frailty is associated with mortality and poorer quality of life (QOL) outcomes in patients undergoing TAVR with a history of cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective single center cohort study included AS patients who underwent TAVR from August 1, 2012 to May 15, 2020. Frailty was measured using serum albumin, hemoglobin, gait speed, functional dependence, and cognitive impairment. The primary outcome was a composite of all\u2010cause mortality and QOL at 1 year. A poor primary outcome was defined as either all\u2010cause mortality, Kansas City Cardiomyopathy Questionnaire overall summary (KCCQ\u2010OS) score &lt;45\u00a0or a KCCQ\u2010OS score decline of \u226510 points from baseline. Regression analysis was used to determine the impact of frailty on the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population was stratified into active\/recent cancer (<jats:italic>n<\/jats:italic>\u2009=\u2009107), remote cancer (<jats:italic>n<\/jats:italic>\u2009=\u200985), and non\u2010cancer (<jats:italic>n<\/jats:italic>\u2009=\u2009448). Univariate analysis of each cohort showed that frailty was associated with the primary outcome only in the non\u2010cancer cohort (<jats:italic>p<\/jats:italic>\u2009=\u2009.004). Multivariate analysis showed that cancer history was not associated with a poor primary outcome, whereas frailty was (1.7 odds ratio, 95% confidence interval [CI]:\u00a01.1\u20132.8; <jats:italic>p<\/jats:italic>\u2009=\u2009.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Frailty is associated with mortality and poor QOL in the overall and non\u2010cancer cohorts. Further investigation is warranted to understand frailty's effect on the cancer population. Frailty should be heavily considered during TAVR evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23927","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T08:19:07Z","timestamp":1664871547000},"page":"977-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of frailty on mortality and quality of life in patients with a history of cancer undergoing transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"45","author":[{"given":"Nikitha","family":"Kosaraju","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of California at Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine and Health Services Research University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Bolano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim M.","family":"Rafique","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Satou","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiac Surgery University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Huchting","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deena","family":"Goldwater","sequence":"additional","affiliation":[{"name":"Welcome Health Medical Group Welcome Health Inc  Long Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olcay","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of California at Los Angeles  Los Angeles California USA"},{"name":"UCLA Cardio\u2010Oncology Program, Department of Medicine, Division of Cardiology University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-7454","authenticated-orcid":false,"given":"Eric H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology University of California at Los Angeles  Los Angeles California USA"},{"name":"UCLA Cardio\u2010Oncology Program, Department of Medicine, Division of Cardiology University of California at Los Angeles  Los Angeles California 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