{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:52:08Z","timestamp":1740145928560,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K23 AG055667"],"award-info":[{"award-number":["K23 AG055667"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse cardiac events are common following transcatheter aortic valve replacement (TAVR). Our aim was to investigate the low left ventricular stroke volume index (LVSVI) 30 days after TAVR as an early echocardiographic marker of survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Steady\u2010state (30\u2010day) LVSVI after TAVR is associated with 1\u2010year mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center retrospective analysis of all patients undergoing TAVR from 2017 to 2019. Baseline and 30\u2010day post\u2010TAVR echocardiographic LVSVI were calculated. Patients were stratified by pre\u2010TAVR transaortic gradient, surgical risk, and change in transvalvular flow following TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This analysis focuses on 238 patients treated with TAVR. The 1\u2010year mortality rate was 9% and 124 (52%) patients had normal flow post\u2010TAVR. Of those with pre\u2010TAVR low flow, 67% of patients did not normalize LVSVI at 30 days. The 30\u2010day normal flow was associated with lower 1\u2010year mortality when compared to low flow (4% vs. 14%, <jats:italic>p<\/jats:italic>\u2009=\u2009.007). This association remained significant after adjusting for known predictors of risk (adjusted odds ratio [OR] of 3.45, 95% confidence interval: 1.02\u201311.63 [per 1\u2009ml\/m<jats:sup>2<\/jats:sup> decrease], <jats:italic>p<\/jats:italic>\u2009=\u2009.046). Normalized transvalvular flow following TAVR was associated with reduced mortality (8%) when compared to those with persistent (15%) or new\u2010onset low flow (12%) (<jats:italic>p<\/jats:italic>\u2009=\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LVSVI at 30 days following TAVR is an early echocardiographic predictor of 1\u2010year mortality and identifies patients with worse intermediate outcomes. More work is needed to understand if this short\u2010term imaging marker might represent a novel therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23937","type":"journal-article","created":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T19:24:31Z","timestamp":1666553071000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Left ventricular stroke volume index following transcatheter aortic valve replacement is an early predictor of 1\u2010year survival"],"prefix":"10.1002","volume":"46","author":[{"given":"Shiva K.","family":"Annamalai","sequence":"first","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin C.","family":"Koethe","sequence":"additional","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Simsolo","sequence":"additional","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dou","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Connors","sequence":"additional","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles D.","family":"Resor","sequence":"additional","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Weintraub","sequence":"additional","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natesa G.","family":"Pandian","sequence":"additional","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C.","family":"Downey","sequence":"additional","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayan R.","family":"Patel","sequence":"additional","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-1426","authenticated-orcid":false,"given":"Benjamin S.","family":"Wessler","sequence":"additional","affiliation":[{"name":"The CardioVascular Center Tufts Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"e35","article-title":"2020 ACC\/AHA Guideline for the Management of Patients with Valvular Heart Disease: a Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelinesclinical practice guidelines","volume":"143","author":"Otto CM","year":"2021","journal-title":"Circulation"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.004693"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306151"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.044"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/24748706.2020.1782549"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.03.038"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.0759"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.02.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-307067"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.3425"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01461-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01509-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.01.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.027"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.3.425"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.03.020"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw096"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.07.014"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23937","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T02:34:45Z","timestamp":1692498885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,23]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/clc.23937"],"URL":"https:\/\/doi.org\/10.1002\/clc.23937","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"type":"print","value":"0160-9289"},{"type":"electronic","value":"1932-8737"}],"subject":[],"published":{"date-parts":[[2022,10,23]]},"assertion":[{"value":"2022-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}