{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:00:12Z","timestamp":1770750012908,"version":"3.50.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Renal and liver dysfunctions are risk factors for mortality in patients with severe aortic stenosis (AS). Transcatheter aortic valve implantation (TAVI) has the potential to break the vicious cycle between AS and hepatorenal dysfunction by relieving aortic valve obstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>A part of patients can derive hepatorenal function improvement from TAVI, and this noncardiac benefit improves the\u00a0intermediate\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed this retrospective cohort study in 439 consecutive patients undergoing TAVI and described the dynamic hepatorenal function assessed by model for end\u2010stage liver disease\u00a0model for end\u2010stage liver disease (MELD)\u2010XI score in subgroups. The endpoint was 2\u2010year all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Receiver\u2010operating characteristic analysis showed that the baseline MELD\u2010XI score of 10.71 was the cutoff point. A high MELD\u2010XI score (&gt;10.71) at baseline was an independent predictor of the 2\u2010year mortality hazard ratio\u00a0(HR: 2.65 [1.29\u20135.47], <jats:italic>p<\/jats:italic>\u2009=\u2009.008). After TAVI, patients with irreversible high MELD\u2010XI scores had a higher risk of 2\u2010year mortality than patients who improved from high to low MELD\u2010XI scores (HR: 2.50 [1.06\u20135.91], <jats:italic>p<\/jats:italic>\u2009=\u2009.03). Factors associated with reversible MELD\u2010XI scores improvement were low baseline MELD\u2010XI scores (\u226412.00, odds ratio [OR]: 2.02 [1.04\u20133.94], <jats:italic>p<\/jats:italic>\u2009=\u2009.04), high aortic valve peak velocity (\u22655\u2009m\/s, OR: 2.17 [1.11\u20134.24], <jats:italic>p<\/jats:italic>\u2009=\u2009.02), and low body mass index\u00a0(\u226425\u2009kg\/m<jats:sup>2<\/jats:sup>, OR: 2.73 [1.25\u20135.98], <jats:italic>p<\/jats:italic>\u2009=\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High MELD\u2010XI score at baseline is an independent predictor for 2\u2010year mortality. Patients with hepatorenal function improvement after TAVI have better outcomes. For patients with irreversible hepatorenal dysfunction after TAVI, further optimization of the subsequent treatment after TAVI is needed to improve the outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23940","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T09:42:20Z","timestamp":1669801340000},"page":"84-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic value of the dynamic hepatorenal function on intermediate\u2010term mortality in TAVI patients with survival to discharge"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-7535","authenticated-orcid":false,"given":"Yijun","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University  Chengdu 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