{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:58:23Z","timestamp":1789750703617,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"Abstract<\/jats:title>\n \n \n \n Left atrial appendage occlusion is not inferior to oral anticoagulants in the prevention of stroke in several randomized controlled trials. However, the clinical efficacy and safety comparison of the Watchman and amplatzer cardiac plug (ACP)\/Amulet devices for percutaneous left atrial appendage closure (LAAC) in patients with non\u2010valvular atrial fibrillation was controversial.\u00a0A database search was conducted using PubMed, EMBASE, Cochrane Library, and\n Clinicaltrials.gov<\/jats:ext-link>\n for trials that compared Watchman device vs ACP\/Amulet device. The effective outcomes were stroke and systemic embolism. Safety outcomes were all\u2010cause death, cardiovascular death, and major bleeding. Device\u2010related complications included device\u2010related thrombus (DRT), peri\u2010device leaks (PDL\u2009>\u20095\u2009mm).\u00a0A total of 19 articles involving 6224 patients were included in the present study. The Watchman and ACP\/Amulet groups comprised 3267 and 2957 patients, respectively. No statistically significant differences were detected in the stroke (odd ratio [OR]:1.24, 95% confidence interval [CI]: 0.92\u22121.67,\n p<\/jats:italic>\n \u2009=\u2009.17,\u00a0\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090), systemic embolism (OR:1.10, 95%\u00a0CI: 0.51\u22122.35,\n p<\/jats:italic>\n \u2009=\u2009.81,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090%), all\u2010cause death (OR:0.97, 95%\u00a0CI: 0.80\u22121.18,\n p<\/jats:italic>\n \u2009=\u2009.77,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20091%), cardiogenic death (OR:0.99, 95%\u00a0CI: 0.77\u22121.29,\n p<\/jats:italic>\n \u2009=\u2009.96,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090%), major bleeding (OR:1.18, 95%\u00a0CI: 0.98\u22121.43,\n p<\/jats:italic>\n \u2009=\u2009.08,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200925%). DRT (OR:1.48, 95%\u00a0CI: 1.06\u22122.06,\n p<\/jats:italic>\n \u2009=\u2009.02,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090%) and PDL\u2009>\u20095\u2009mm (OR:2.57, 95%\u00a0CI: 1.63\u22124.04,\n p<\/jats:italic>\n \u2009<\u2009.0001,\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090%) were significantly lower in ACP\/Amulet group compared to Watchman group.\u00a0The effective and safety outcomes were comparable between two groups. ACP\/Amulet group had significantly lower rates of DRT and PDL\u2009>\u20095\u2009mm than Watchman group.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/clc.23956","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T04:36:02Z","timestamp":1669782962000},"page":"117-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical efficacy and safety comparison of Watchman device versus\u00a0ACP\/Amulet device for percutaneous left atrial appendage closure in patients with nonvalvular atrial fibrillation: A study\u2010level meta\u2010analysis of clinical trials"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-9850","authenticated-orcid":false,"given":"Sun","family":"Bing","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tang du Hospital Air Force Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tang du Hospital Air Force Medical University Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000665"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.114389"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.021"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa169"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.08.025"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25230"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25297"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-1134"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26678"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0899-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2018.10.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4244\/AIJ-D-18-00013"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-01027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2352648"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.10.010"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2021.100893"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.09.051"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057063"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-021-01002-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29795"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057859"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-022-02708-4"},{"key":"e_1_2_7_27_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions. 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