{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:24:16Z","timestamp":1761582256800,"version":"3.37.3"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009664","name":"Sociedad Espa\u00f1ola de Cardiolog\u00eda","doi-asserted-by":"publisher","award":["Investigaci\u00f3n Cl\u00ednica en Cardiolog\u00eda","Grant SEC"],"award-info":[{"award-number":["Investigaci\u00f3n Cl\u00ednica en Cardiolog\u00eda","Grant SEC"]}],"id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left bundle branch block (LBBB) has been commonly associated with adverse cardiovascular (CV) events, but the effect of an isolated LBBB on maximal functional capacity is not well characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate maximal functional capacity in adults with isolated LBBB and compare it to healthy population\u2010derived predicted values (adjusted for sex, age, weight, and height).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This descriptive pilot study included subjects with isolated LBBB derived from outpatient clinics of two academic hospitals. All subjects underwent maximal cardiopulmonary exercise testing (CPET) and a Global Physical Activity Questionnaire (GPAQ). The primary outcome was to evaluate maximal functional capacity according to population\u2010derived predicted values of peak oxygen consumption (peakVO<jats:sub>2<\/jats:sub>): pp\u2010peakVO<jats:sub>2<\/jats:sub>. The secondary outcome was to report adverse CV events (CV deaths or hospitalizations) at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 27 (18 women and 9 men) participants were included. The median (interquartile range) age of the sample and time to screening from the first LBBB diagnosis were 62 (51\u221271) and 3.4 (1.1\u22128.4) years, respectively. The results of the GPAQ score showed that 19 patients were highly active, and 8 were moderately active. The median of peakVO<jats:sub>2<\/jats:sub> and pp\u2010peakVO<jats:sub>2<\/jats:sub> were 19.3 (15\u221222.5)\u2009ml\/kg\/min and 88% (79.3%\u2212104.4%), respectively. There were no adverse CV events at a median follow\u2010up after CPET of 3.1 (2.7\u22123.4) years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this pilot study, adults with isolated LBBB showed reduced maximal functional capacity, despite the absence of cardiac disease and a baseline moderate to highly active lifestyle.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23977","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T08:07:45Z","timestamp":1675930065000},"page":"386-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maximal functional capacity in subjects with isolated left bundle branch block: A pilot study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-0924","authenticated-orcid":false,"given":"Patricia","family":"Palau","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, INCLIVA Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Mendez","sequence":"additional","affiliation":[{"name":"Cardiology Department IMED Elche Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Santas","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, INCLIVA Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-7119","authenticated-orcid":false,"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, INCLIVA Universitat de Val\u00e8ncia Valencia Spain"},{"name":"CIBER Cardiovascular Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Facultad de Fisioterapia Universitat de Val\u00e8ncia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Briatore","sequence":"additional","affiliation":[{"name":"Fisabio Universitat Jaume I Castell\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloy","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico Universitario, INCLIVA Universitat de Val\u00e8ncia Valencia Spain"},{"name":"Fisabio Universitat Jaume I Castell\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)00160-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a062172"},{"issue":"6","key":"e_1_2_10_4_1","first-page":"258","article-title":"asymptomatic left bundle branch block predicts new\u2010onset congestive heart failure and death from cardiovascular diseases","author":"Azadani PN","year":"2012","journal-title":"Cardiol Res"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux061"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0457-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.2166"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.010"},{"key":"e_1_2_10_9_1","first-page":"160","volume-title":"Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications","author":"Wasserman K","year":"2005"},{"key":"e_1_2_10_10_1","first-page":"11","article-title":"Cardiopulmonary exercise testing in patients with left bundle branch block and preserved ejection fraction","volume":"30","author":"Barros MS","year":"2017","journal-title":"In. J Cardiovasc Sci"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.23977","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.23977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T19:37:02Z","timestamp":1692473822000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.23977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,8]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/clc.23977"],"URL":"https:\/\/doi.org\/10.1002\/clc.23977","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"type":"print","value":"0160-9289"},{"type":"electronic","value":"1932-8737"}],"subject":[],"published":{"date-parts":[[2023,2,8]]},"assertion":[{"value":"2022-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}