{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:10:45Z","timestamp":1782180645659,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010density lipoprotein cholesterol (LDL\u2010C) lowering is key to reduce atherosclerotic disease progression and recurrent events for patients after acute coronary syndrome (ACS). However, LDL\u2010C management for post\u2010ACS patients remains challenging in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>The ACS EuroPath III project was designed to optimize LDL\u2010C management in post\u2010ACS patients by promoting guideline implementation and translating existing evidence into effective actions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three surveys targeting cardiologists (<jats:italic>n<\/jats:italic>\u2009=\u2009555), general practitioners (GPs; <jats:italic>n<\/jats:italic>\u2009=\u2009445), and patients (<jats:italic>n<\/jats:italic>\u2009=\u2009662) were conducted in Europe, with the aim of capturing information on patient characteristics and treatment during acute phase, discharge and follow\u2010up. GPs\u2019 and patients\u2019 opinions on key treatment aspects were also collected. Based on survey results, international experts and clinicians identified areas of improvement and generated prototype solutions. Participants voted to select the most feasible and replicable proposals for co\u2010development and implementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five key areas of improvement were identified: (1) inappropriate treatment prescribed at discharge; (2) lack of lipid guidance in the discharge letter; (3) inadequate lipid\u2010lowering therapy (LLT) optimization; (4) gaps in guideline knowledge and lack of referral practices for GPs; (5) patients\u2019 concerns about lipid management. Proposed solutions for these focus areas included development of a treatment algorithm for the acute phase, a standardized GP discharge letter, an assessment tool for LLT efficacy at follow\u2010up, an education plan for GPs\/patients and a patient engagement discharge kit. The standardized GP discharge letter and treatment algorithm have been selected as the highest priority solutions for development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These initiatives have the potential to improve adherence to guidelines and patient management after ACS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.23988","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T08:56:52Z","timestamp":1676624212000},"page":"407-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Addressing current challenges in optimization of lipid management following an ACS event: Outcomes of the ACS EuroPath III initiative"],"prefix":"10.1002","volume":"46","author":[{"given":"Alberico L.","family":"Catapano","sequence":"first","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Caterina","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular, Department of Cardiothoracic and Vascular, Pisa University Hospital, University of Pisa, Pisa, Azienda Ospedaliero\u2010Universitaria Pisana, Pisa, and Fondazione Villaserena per la Ricerca Citt\u00e0 Sant'Angelo Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3246-8359","authenticated-orcid":false,"given":"J. Wouter","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology Leiden University Medical Center Leiden The Netherlands"},{"name":"Netherlands Heart Institute Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klempfner","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Institute, Sheba Medical Center Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 University Medicine Berlin, German Centre for Cardiovascular Research (DZHK), Partner Site Berlin Berlin Institute of Health (BIH) Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Schiele","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Burgundy Franche\u2010Comte University Hospital Jean Minjoz Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-9512","authenticated-orcid":false,"given":"Alessandro","family":"Sionis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital de la Santa Creu i Sant Pau, IIB\u2010Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5334\/aogh.2713"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.06.33"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.2049"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2021.01.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.03.014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwaa047"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2021.01.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2021.01.011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2020.06.027"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161493","article-title":"Early discharge in low\u2010risk patients hospitalized for acute coronary syndromes: feasibility, safety and reasons for prolonged length of stay","volume":"118","author":"Laurencet ME","year":"2016","journal-title":"PLoS One"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-021-06345-z"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105499"},{"key":"e_1_2_10_17_1","first-page":"4","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). 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