{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:20:33Z","timestamp":1791908433935,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ratio of platelets to lymphocytes (PLR) can serve as a potential biomarker for predicting the prognosis of individuals with acute myocardial infarction (AMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of the research was to evaluate the in\u2010hospital outcomes of AMI patients and the predictive significance of PLR on major adverse cardiac events (MACE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 799 AMI patients who had successful primary PCI within 12\u2009h of the onset of chest pain were separated into low PLR (<jats:italic>n<\/jats:italic>\u2009=\u2009511) and high PLR (<jats:italic>n<\/jats:italic>\u2009=\u2009288) groups using a PLR cutoff value of 178. At admission, total white blood cell, neutrophil, lymphocyte, and platelet counts were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with a high PLR group with PLR\u2009&gt;\u2009178, the incidence of MACE: heart rupture, acute heart failure, total adverse events, and mortality due to all events was considerably greater. In an analysis of the receiver operating characteristic curve, a high PLR\u2009&gt;\u2009178 accurately predicted adverse outcomes (73% specificity and 65% sensitivity). Age, hypertension, and PLR were found as independent predictors of adverse outcomes by multiple logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AMI patients with high PLR had poor hospital outcomes. These findings recommend PLR as an independent risk factor for hospital\u2010acquired complications, suggesting that inflammation and prothrombotic state may contribute to the poor prognosis of high PLR patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24002","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T05:40:11Z","timestamp":1681537211000},"page":"632-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Platelet\u2010to\u2010lymphocyte ratio a potential prognosticator in acute myocardial infarction: A prospective longitudinal study"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-4914","authenticated-orcid":false,"given":"Hongling","family":"Wang","sequence":"first","affiliation":[{"name":"Second Department of Cardiology Tangshan Gongren Hospital Tangshan Hebei 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