{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:26:51Z","timestamp":1778628411827,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (AF) associates with higher Alzheimer's disease (AD) and vascular dementia risks but the clinical implications have been scarcely investigated. We examined the association between AD or vascular dementia and adverse outcomes in AF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cohort study between January 2000 and 2017. AF patients were divided into two groups according to vascular dementia or AD, and balanced using propensity score matching (PSM). During 4\u2010years of follow\u2010up, incident intracranial hemorrhages (ICH), the composite of ischemic stroke\/transient ischemic attack (TIA), hospitalizations, and all\u2010cause deaths, were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two thousand three hundred seventy\u2010seven AF patients with dementia (1225 with vascular dementia, and 1152 with AD) were identified. Following a PSM, 615 patients were included in each cohort (i.e., 1:1) and all variables were well\u2010matched. After PSM, 22 (3.6%) patients with vascular dementia and 55 (8.1%) patients with AD had incident ICH during follow\u2010up (hazard ratio [HR]: 2.22, 95% confidence interval [CI]: 1.33\u22123.70, log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Overall, 237 (38.5%) patients with vascular dementia and 193 (31.4%) patients with AD, developed an ischemic stroke\/TIA. The risk of ischemic stroke\/TIA was 1.32\u2010fold higher in vascular dementia (HR: 1.32, 95% CI: 1.09\u22121.59, log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.003). The risk of rehospitalization (HR: 1.14, 95% CI: 1.01\u22121.31), and mortality (HR: 1.25, 95% CI: 1.01\u22121.58) were also higher among AF patients with vascular dementia compared to AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The two forms of dementia in AF patients are associated with different prognosis, with AD being associated with a higher risk of ICH, and vascular dementia with a higher risk of stroke\/TIA, hospitalization, and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24006","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T05:47:44Z","timestamp":1681192064000},"page":"656-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical implications of different types of dementia in patients with atrial fibrillation: Insights from a global federated health network analysis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-7030","authenticated-orcid":false,"given":"Riccardo","family":"Proietti","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool Heart &amp; Chest Hospital Liverpool John Moores University Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-6241","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Rivera\u2010Caravaca","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool Heart &amp; Chest Hospital Liverpool John Moores University Liverpool UK"},{"name":"Faculty of Nursing University of Murcia Murcia Spain"},{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), CIBERCV University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"L\u00f3pez\u2010G\u00e1lvez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), CIBERCV University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool Heart &amp; Chest Hospital Liverpool John Moores University Liverpool UK"},{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J. R.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool Heart &amp; Chest Hospital Liverpool John Moores University Liverpool UK"},{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB\u2010Arrixaca), CIBERCV University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Underhill","sequence":"additional","affiliation":[{"name":"TriNetX LLC London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Shantsila","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool Heart &amp; Chest Hospital Liverpool John Moores University Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Shantsila","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool Heart &amp; Chest Hospital Liverpool John Moores University Liverpool UK"},{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhys","family":"Davies","sequence":"additional","affiliation":[{"name":"The Walton Centre NHS Foundation Trust, Lower Lane, UK Liverpool"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre A.","family":"Lane","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool Heart &amp; Chest Hospital Liverpool John Moores University Liverpool UK"},{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool Heart &amp; Chest Hospital Liverpool John Moores University Liverpool UK"},{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"KalantarianS SternTA MansourM RuskinJN. Annals of internal medicine cognitive impairment associated with atrial fibrillation.2015."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.07.026"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000984"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.077"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000917"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_8_8_1","first-page":"020","article-title":"2021 focused update consensus guidelines of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation: executive summary *","volume":"122","author":"Chao TF","year":"2021","journal-title":"Thromb Haemost"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13480"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160527"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2008.03.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.212"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-018-1052-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70236-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.153"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1515-9630"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061696"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.24006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T17:10:45Z","timestamp":1692465045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.24006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/clc.24006"],"URL":"https:\/\/doi.org\/10.1002\/clc.24006","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]},"assertion":[{"value":"2022-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}