{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:33:04Z","timestamp":1771471984074,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Risk stratification for transcatheter procedures in patients with severe mitral regurgitation is challenging. Deceleration capacity (DC) has already proven to be a reliable risk predictor in patients undergoing transcatheter aortic valve implantation. We hypothesized, that DC provides prognostic value in patients undergoing transcatheter edge\u2010to\u2010edge mitral valve repair (TEER).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed electrocardiogram signals from 106 patients undergoing TEER at the University Hospital of T\u00fcbingen. All patients received continuous heart\u2010rate monitoring to assess DC following the procedure. One\u2010year all\u2010cause mortality was defined as the primary end point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen patients (15.1%) died within 1 year. The DC in nonsurvivors was significantly reduced compared to survivors (5.1\u2009\u00b1\u20093.0 vs. 3.0\u2009\u00b1\u20091.6\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). A higher EuroSCORE II and impaired left ventricular function were furthermore associated with poor outcome. In Cox regression analyses, a DC\u2009&lt;\u20094.5\u2009ms was found a strong predictor of 1\u2010year mortality (hazard ratio: 0.10, 95% confidence interval: 0.13\u20130.79, <jats:italic>p<\/jats:italic>\u2009=\u20090.029). Finally, a significant negative correlation was found between DC and residual mitral regurgitation after TEER (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.41, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with severe mitral regurgitation undergoing TEER, DC may serve as a new predictor of follow\u2010up mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24007","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T10:59:51Z","timestamp":1679482791000},"page":"529-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deceleration capacity of heart rate predicts 1\u2010year mortality in patients undergoing transcatheter edge\u2010to\u2010edge mitral valve repair"],"prefix":"10.1002","volume":"46","author":[{"given":"Lars","family":"Mizera","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Rath","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Schreieck","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Seizer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Ostalbklinikum Aalen Aalen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinrad Paul","family":"Gawaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Duckheim","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2279-3166","authenticated-orcid":false,"given":"Christian","family":"Eick","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-430X","authenticated-orcid":false,"given":"Karin A. L.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezab389"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.018"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1289"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1774"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805374"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22748"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68735-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000922"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2018.06.016"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2021.07.016"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq031"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs043"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12107"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.03.003"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx402"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.09.051"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv627"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12193"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.04.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.041"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.02.084"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23258"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001039"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137464"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.24007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/clc.24007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.24007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T17:51:13Z","timestamp":1692553873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.24007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/clc.24007"],"URL":"https:\/\/doi.org\/10.1002\/clc.24007","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,22]]},"assertion":[{"value":"2022-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}