{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:09:27Z","timestamp":1785283767118,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited comparative data on safety and efficacy within commonly used Vaughan\u2010Williams (VW)\u00a0class III antiarrhythmic drugs (AADs)\u00a0for maintenance of sinus rhythm in adults with atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that dronedarone and sotalol, two commonly prescribed VW class III AADs with class II properties, have different safety and efficacy effects in patients with nonpermanent AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature review was conducted searching MEDLINE\u00ae, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL)\u00a0up to June 15, 2021 (NCT05279833).\u00a0Clinical trials and observational studies that evaluated safety and efficacy of dronedarone or sotalol in adults with AF were included. Bayesian random\u2010effects network meta\u2010analysis (NMA)\u00a0was used to quantify comparative safety and efficacy. Where feasible, we performed sensitivity analyses by including only randomized controlled trials (RCTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 3581 records identified through database searches, 37 unique studies (23 RCTs, 13 observational studies, and 1 nonrandomized trial) were included in the NMA. Dronedarone was associated with a statistically significantly lower risk of all\u2010cause death versus sotalol (hazard ratio [HR]\u2009=\u20090.38 [95% credible interval, CrI: 0.19, 0.74]). The association was numerically similar in the sensitivity analysis (HR\u2009=\u20090.46 [95% CrI: 0.21, 1.02]). AF recurrence and cardiovascular death results were not significantly different between dronedarone and sotalol in all\u2010studies and sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The NMA findings indicate that, across all clinical trials and observational studies included, dronedarone compared with sotalol was associated with a lower risk of all\u2010cause death, but with no difference in AF recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24011","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T06:14:56Z","timestamp":1680848096000},"page":"589-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dronedarone versus sotalol in patients with atrial fibrillation: A systematic literature review and network meta\u2010analysis"],"prefix":"10.1002","volume":"46","author":[{"given":"Jagmeet P.","family":"Singh","sequence":"first","affiliation":[{"name":"Cardiology Division, Harvard Medical School Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Blomstr\u00f6m\u2010Lundqvist","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"},{"name":"Department of Medical Science Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mintu P.","family":"Turakhia","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiovascular Medicine), Center for Digital Health Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-2871","authenticated-orcid":false,"given":"A. 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