{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:33:43Z","timestamp":1789594423137,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Currently, there is controversy regarding the treatment of pregnant patients with mild hypertension (blood pressure 140\u2013159\/90\u2013109\u2009mm\u2009Hg). While guidelines do not recommend this treatment, results from recent clinical trials are supportive of the treatment. This meta\u2010analysis aimed to clarify if active treatment of mild hypertension during pregnancy results in better maternal and fetal outcomes. All of the potentially eligible randomized controlled trials were retrieved through a systematic database search investigating the impact of pharmacological treatment in mild hypertensive patients on maternal, fetal, and neonatal outcomes. Relative risk (RR) and 95% confidence interval (CI) were calculated using a random\u2010effects model. Data from 12 trials comprising 4461 pregnant women diagnosed with mild to moderate hypertension (2395 in the intervention group and 2066 in the control group) were extracted for quantitative synthesis. Antihypertensive treatment was associated with better outcomes in seven out of the 19 analyzed outcomes: Severe hypertension (RR\u2009=\u20090.53; 95% CI\u2009=\u2009[0.38;0.75]), preeclampsia (RR\u2009=\u20090.71; 95% CI\u2009=\u2009[0.54; 0.93]), placental abruption (RR\u2009=\u20090.48; 95% CI\u2009=\u2009[0.26; 0.87]), changes in electrocardiogram (RR\u2009=\u20090.43; 95% CI\u2009=\u2009[0.25; 0.72]), renal impairment (RR\u2009=\u20090.42; 95% CI\u2009=\u2009[0.34; 0.51]), pulmonary edema (RR\u2009=\u20090.46; 95% CI\u2009=\u2009[0.25; 0.84]), and neonatal mortality (RR\u2009=\u20090.72; 95% CI\u2009=\u2009[0.57; 0.92]). The primary safety outcome of small for gestational age was not different between the treatment group and the control group (RR\u2009=\u20091.12; 95% CI\u2009=\u2009[0.80; 1.57]). The results of this meta\u2010analysis are in favor of the beneficial impact of pharmacological treatment of mild hypertension on both maternal and neonatal outcomes and without significant adverse events for the fetus.<\/jats:p>","DOI":"10.1002\/clc.24013","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T05:27:45Z","timestamp":1680067665000},"page":"467-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The impact of antihypertensive treatment of mild to moderate hypertension during pregnancy on maternal and neonatal outcomes: An updated meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-4870","authenticated-orcid":false,"given":"Armin","family":"Attar","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4175-8059","authenticated-orcid":false,"given":"Alireza","family":"Hosseinpour","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Moghadami","sequence":"additional","affiliation":[{"name":"Clinical Education Research Center, Department of Medicine Shiraz University of Medical Sciences  Shiraz 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