{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:48:15Z","timestamp":1781765295783,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To establish an association between beta\u2010blockers (BBs), calcium channel blockers (CCBs), all\u2010cause mortality, and hospitalization in patients with Heart failure with preserved Ejection Fraction (HFpEF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present meta\u2010analysis has been performed as per the guidelines of (PRISMA). An inclusive literature search was made without any limitations on language using the electronic databases Cochrane Library, EMBASE, and PubMed up to November 2022. The outcomes evaluated in this meta\u2010analysis involved all\u2010cause mortality and hospitalization due to heart failure. The number of patients with HFpEF and their positive outcomes was extracted and analyzed using RevMan software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 10 articles were included in the present meta\u2010analysis, with a pooled sample size of 12\u2009940 HFpEF patients. In comparison with placebo, both BB and CCB substantially reduced the risk of all\u2010cause mortality and hospitalization. However, BB are more effective because they provide a significant reduction in all\u2010cause mortality (risk ratio (RR)\u2009=\u20090.60; 95% confidence interval [CI]\u2009=\u20090.43\u20130.83; <jats:italic>p<\/jats:italic>\u2009=\u2009.002] and hospitalization (RR\u2009=\u20090.54; 95% CI\u2009=\u20090.37\u20130.80; <jats:italic>p<\/jats:italic>\u2009=\u2009.002) as compared with CCB with a risk ratio of all\u2010cause mortality (RR\u2009=\u20090.77; 95% CI\u2009=\u20090.60\u20130.98; <jats:italic>p<\/jats:italic>\u2009=\u2009.03) and hospitalization (RR\u2009=\u20090.63; 95% CI\u2009=\u20090.44\u20130.90; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.00001). A random\u2010effects model was used because of high heterogeneity between the studies (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009&gt;\u200970%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current meta\u2010analysis suggests that BBs were more beneficial than CCB in reducing all\u2010cause mortality and hospitalization duration in patients with HFpEF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24058","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T15:49:49Z","timestamp":1686152989000},"page":"845-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between the beta\u2010blockers, calcium channel blockers, all\u2010cause mortality and length of hospitalization in patients with heart failure with preserved ejection fraction: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"46","author":[{"given":"Mingming","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology Jiangsu Rudong County People's Hospital Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Meishan People's Hospital Sichuan Meishan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010ling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jiangsu Rudong County People's Hospital Nantong Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8596-812X","authenticated-orcid":false,"given":"Shengjun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medical College Wuhan Railway Vocational College of Technology Wuhan Hubei 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