{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:01:34Z","timestamp":1773014494604,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Transcatheter aortic valve replacement (TAVR)\u00a0has become a widely used therapy for patients with severe aortic stenosis. Carbohydrate antigen 125 (CA\u2010125) is a promising biomarker in some cardiovascular diseases. This systematic review aims to assess the prognostic role of CA\u2010125 in patients undergoing TAVR. We searched electronic databases from inception to March 2023 to include cohort studies evaluating the association between preprocedural CA\u2010125\u00a0levels and mortality or heart failure (HF)\u00a0readmission at 12 months in patients undergoing TAVR. We pooled crude (cHR)\u00a0and adjusted hazard ratios (aHR)\u00a0with their 95% confidence interval (CI)\u00a0using a random\u2010effects model. The risk of bias was evaluated using the QUIPS tool. The certainty of the evidence was assessed using the GRADE approach. We included five cohort studies involving 1594 patients. Higher levels of CA\u2010125\u00a0were significantly associated with an increased risk of mortality or HF readmission using crude (cHR 2.79, 95% CI 1.45\u20135.36, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009\u200972%) and adjusted (aHR\u00a03.27, 95% CI 2.07\u20135.18, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009\u20090%, high certainty) effect estimates compared with lower levels. Similarly, there was also associated with increased mortality using crude (cHR 2.68, 95% CI 1.99\u20133.60, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009\u20090%) and adjusted (aHR\u00a02.17, 95% CI 1.54\u20133.07, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009\u20090%, high certainty) effect estimates. The risk of bias varied between low to moderate across studies. Our meta\u2010analysis suggests that CA\u2010125\u00a0has incremental prognostic value in patients undergoing TAVR. Further studies are needed to determine the clinical utility of CA\u2010125 in guiding treatment decisions in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.24064","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T04:39:53Z","timestamp":1689655193000},"page":"1129-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic role of CA\u2010125 in patients undergoing transcatheter aortic valve replacement: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-2832","authenticated-orcid":false,"given":"Carlos","family":"Diaz\u2010Arocutipa","sequence":"first","affiliation":[{"name":"Vicerrectorado de Investigaci\u00f3n Universidad San Ignacio de Loyola Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Saucedo\u2010Chinchay","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Nacional Edgardo Rebagliati Martins Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research Keele University Keele UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2019.04.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123730"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.12.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.11.020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29067"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4597"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-4-201302190-00009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.12.023"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"100","article-title":"Evaluation 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